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Semin Thromb Hemost 2023; 49(03): 255-271
DOI: 10.1055/s-0042-1758821
Review Article

Antiplatelet Therapy in Coronary Artery Disease: Now and Then

Maximilian Tscharre
1   Department of Internal Medicine, Cardiology and Nephrology, Landesklinikum Wiener Neustadt, Wiener Neustadt, Austria
2   Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria
,
Thomas Gremmel
2   Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria
3   Department of Internal Medicine I, Cardiology and Intensive Care Medicine, Landesklinikum Mistelbach-Gänserndorf, Mistelbach, Austria
4   Institute of Antithrombotic Therapy in Cardiovascular Disease, Karl Landsteiner Society, St. Pölten, Austria
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Abstract

Cardiovascular disease, particularly coronary artery disease (CAD), remains the leading cause of mortality and morbidity in industrialized countries. Platelet activation and aggregation at the site of endothelial injury play a key role in the processes ultimately resulting in thrombus formation with vessel occlusion and subsequent end-organ damage. Consequently, antiplatelet therapy has become a mainstay in the pharmacological treatment of CAD. Several drug classes have been developed over the last decades and a broad armamentarium of antiplatelet agents is currently available. This review portrays the evolution of antiplatelet therapy, and provides an overview on previous and current antiplatelet drugs and strategies.

Keywords

Coronary artery disease - antiplatelet therapy - aspirin - P2Y12 inhibitors - glycoprotein Ilb/Illa inhibitors - protease-activated receptor 1 antagonists


Publication History

Article published online:
01 December 2022

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