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CC BY-NC-ND 4.0 · Indian J Plast Surg 2022; 55(04): 364-367
DOI: 10.1055/s-0042-1759498
Original Article

Etiopathological Factors Associated with Gynecomastia Patients Seeking Surgical Correction in the South Indian Population

L.S. Sreelesh 
1   Department of Plastic Surgery, Government Medical College, Kozhikode, Kerala, India
,
Sheeja Rajan 
1   Department of Plastic Surgery, Government Medical College, Kozhikode, Kerala, India
,
A. K. Anu
1   Department of Plastic Surgery, Government Medical College, Kozhikode, Kerala, India
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Abstract

Background Although several medical conditions are associated with gynecomastia, around 60% of cases are idiopathic. The role of endocrine testing in idiopathic gynecomastia is controversial. This study was done to determine the etiological and lifestyle factors associated with different grades of gynecomastia.

Patients and Methods This was a descriptive study conducted at the department of plastic surgery in a tertiary care hospital in South India between January 2014 and December 2016, among the patients seeking corrective surgery for gynecomastia.

Results A total of 73 patients were included in the study with a mean age of 22.56 years. The majority of the patients displayed Simon's Grade IIa gynecomastia (56.2%). The etiological factors identified in this study were hormonal abnormalities (47.95%), hypogonadism (2.7%), and drug intake (1.4%). The most common hormonal abnormality discovered was high estradiol values (15.1%) followed by decreased testosterone levels (13.7%). The chi-squared test revealed no statistically significant relationship between the hormonal values, type of food, body mass index (BMI), or physical activity and the grades of gynecomastia.

Conclusion Most of the patients (50.68%) in our study had idiopathic gynecomastia. The most common hormonal abnormality detected was high estradiol values. No correlation was found between the hormonal values, type of food, BMI, or physical activity and the grades of gynecomastia.

Keywords

gynecomastia - etiology - lifestyle factors - hormone assay


Publication History

Article published online:
22 December 2022

© 2022. Association of Plastic Surgeons of India. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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  • References

  • 1 Niewoehner CB, Nuttal FQ. Gynecomastia in a hospitalized male population. Am J Med 1984; 77 (04) 633-638
    CrossrefPubMedGoogle Scholar
  • 2 Lee PA. The relationship of concentrations of serum hormones to pubertal gynecomastia. J Pediatr 1975; 86 (02) 212-215
    CrossrefPubMedGoogle Scholar
  • 3 Johnson RE, Murad MH. Gynecomastia: pathophysiology, evaluation, and management. Mayo Clin Proc 2009; 84 (11) 1010-1015
    CrossrefPubMedGoogle Scholar
  • 4 Ersöz Hö, Onde ME, Terekeci H, Kurtoglu S, Tor H. Causes of gynaecomastia in young adult males and factors associated with idiopathic gynaecomastia. Int J Androl 2002; 25 (05) 312-316
    CrossrefPubMedGoogle Scholar
  • 5 Kumanov P, Deepinder F, Robeva R, Tomova A, Li J, Agarwal A. Relationship of adolescent gynecomastia with varicocele and somatometric parameters: a cross-sectional study in 6200 healthy boys. J Adolesc Health 2007; 41 (02) 126-131
    CrossrefPubMedGoogle Scholar
  • 6 Johnson RE, Kermott CA, Murad MH. Gynecomastia - evaluation and current treatment options. Ther Clin Risk Manag 2011; 7: 145-148
    PubMedGoogle Scholar
  • 7 Handschin AE, Bietry D, Hüsler R, Banic A, Constantinescu M. Surgical management of gynecomastia–a 10-year analysis. World J Surg 2008; 32 (01) 38-44
    CrossrefPubMedGoogle Scholar
  • 8 Longheu A, Medas F, Corrias F. et al. Surgical management of gynecomastia: experience of a general surgery center. G Chir 2016; 37 (04) 150-154
    PubMedGoogle Scholar
  • 9 Simon BE, Hoffman S, Kahn S. Classification and surgical correction of gynecomastia. Plast Reconstr Surg 1973; 51 (01) 48-52
    CrossrefPubMedGoogle Scholar
  • 10 Braunstein GD. What accounts for the increased incidence of gynecomastia diagnosis in Denmark from 1998-2017?. J Clin Endocrinol Metab 2020; 105 (10) e3810-e3811
    CrossrefPubMedGoogle Scholar
  • 11 Kinsella Jr C, Landfair A, Rottgers SA. et al. The psychological burden of idiopathic adolescent gynecomastia. Plast Reconstr Surg 2012; 129 (01) 1-7
    CrossrefPubMedGoogle Scholar
  • 12 Rahmani S, Turton P, Shaaban A, Dall B. Overview of gynecomastia in the modern era and the Leeds Gynaecomastia Investigation algorithm. Breast J 2011; 17 (03) 246-255
    CrossrefPubMedGoogle Scholar
  • 13 MacDonald PC, Madden JD, Brenner PF, Wilson JD, Siiteri PK. Origin of estrogen in normal men and in women with testicular feminization. J Clin Endocrinol Metab 1979; 49 (06) 905-916
    CrossrefPubMedGoogle Scholar
  • 14 Costanzo PR, Pacenza NA, Aszpis SM. et al. Clinical and etiological aspects of gynecomastia in adult males: a multicenter study. BioMed Res Int 2018; 2018: 8364824
    CrossrefPubMedGoogle Scholar
  • 15 Moore DC, Schlaepfer LV, Paunier L, Sizonenko PC. Hormonal changes during puberty: V. Transient pubertal gynecomastia: abnormal androgen-estrogen ratios. J Clin Endocrinol Metab 1984; 58 (03) 492-499
    CrossrefPubMedGoogle Scholar
  • 16 Swerdloff RS, Ng CM. Gynecomastia: etiology, diagnosis, and treatment. In: Feingold KR, Anawalt B, Boyce A. et al., eds. Endotext . MDText.com, Inc.. 2000. http://www.ncbi.nlm.nih.gov/books/NBK279105/ . Accessed May 17, 2022
    Google Scholar
  • 17 Sir E, Üçer O, Aksoy A, Güngör M, Ceylan Y. Sexual function and hormone profile in young adult men with idiopathic gynecomastia: comparison with healthy controls. Breast Dis 2016; 36 (01) 1-4
    CrossrefPubMedGoogle Scholar
  • 18 Al-Alwan I, Al Azkawi H, Badri M, Tamim H, Al Dubayee M, Tamimi W. Hormonal, anthropometric and lipid factors associated with idiopathic pubertal gynecomastia. Ann Saudi Med 2013; 33 (06) 579-583
    CrossrefPubMedGoogle Scholar
  • 19 Yazici M, Sahin M, Bolu E. et al. Evaluation of breast enlargement in young males and factors associated with gynecomastia and pseudogynecomastia. Ir J Med Sci 2010; 179 (04) 575-583
    CrossrefPubMedGoogle Scholar
  • 20 Nuttall FQ. Gynecomastia. Mayo Clin Proc 2010; 85 (10) 961-962
    CrossrefPubMedGoogle Scholar