CC BY 4.0 · European Journal of General Dentistry 2023; 12(01): 001-006
DOI: 10.1055/s-0042-1760673
Review Article

Application of Magnesium Oxide Nanoparticles in Dentistry: A Literature Review

Seyedarsham Sharifian
1   Department of Restorative Dentistry, Ramsar Campus, Mazandaran University of Medical Sciences, Ramsar, Iran
,
Alireza Loghmani
2   Department of Dental Materials and Restorative Dentistry, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran
,
Shiva Nayyerain
3   Department of Dental Materials and Restorative Dentistry, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran
,
Sanaz Javanbakht
4   Independent Researcher, Isfahan, Iran
,
5   Department of Dental Materials and Restorative Dentistry, School of Dentistry, Islamic Azad University of Medical Sciences, Tehran, Iran
› Author Affiliations
Funding None.

Abstract

Magnesium oxide (MgO) nanoparticles' biocompatibility and degraded by-products are the two most important factors that make this material preferable in dental care. Their specific characteristics, such as antibacterial action against cariogenic microbes, are potential antibacterial agents for dental applications. This paper investigates the properties of MgO in dentistry and sets the groundwork for future research. Electronic databases, including PubMed/Medline, Scopus, Google Scholar, and scientific-research journals of domestic universities were reviewed from 1972 to 2022, and all the relevant papers were surveyed. After a search in electronic databases, 60 articles were involved, and the needed details were extracted. The biochemical features and application of magnesium oxide nanoparticles (MgONPs) in dentistry and new fields have been discussed in detail. Nanoparticles (NPs) may provide a unique method for treating and preventing dental infections. MgO nanoparticles are a good choice in several fields because their unique properties, such as antibacterial activity against cariogenic microorganisms, make them ideal antibacterial agents for dental applications.



Publication History

Article published online:
06 June 2023

© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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  • References

  • 1 Medina C, Santos-Martinez MJ, Radomski A, Corrigan OI, Radomski MW. Nanoparticles: pharmacological and toxicological significance. Br J Pharmacol 2007; 150 (05) 552-558
  • 2 Hannig M, Hannig C. Nanomaterials in preventive dentistry. Nat Nanotechnol 2010; 5 (08) 565-569
  • 3 Ahmadian E, Shahi S, Yazdani J, Maleki Dizaj S, Sharifi S. Local treatment of the dental caries using nanomaterials. Biomed Pharmacother 2018; 108: 443-447
  • 4 Moradpoor H, Safaei M, Mozaffari HR. et al. An overview of recent progress in dental applications of zinc oxide nanoparticles. RSC Advances 2021; 11 (34) 21189-21206
  • 5 Krishnamoorthy K, Manivannan G, Kim SJ, Jeyasubramanian K, Premanathan M. Antibacterial activity of MgO nanoparticles based on lipid peroxidation by oxygen vacancy. J Nanopart Res 2012; 14 (09) 1-10
  • 6 Di DR, He ZZ, Sun ZQ, Liu J. A new nano-cryosurgical modality for tumor treatment using biodegradable MgO nanoparticles. Nanomedicine 2012; 8 (08) 1233-1241
  • 7 Noori AJ, Kareem FA. The effect of magnesium oxide nanoparticles on the antibacterial and antibiofilm properties of glass-ionomer cement. Heliyon 2019; 5 (10) e02568
  • 8 Hornak J, Trnka P, Kadlec P. et al. Magnesium oxide nanoparticles: dielectric properties, surface functionalization and improvement of epoxy-based composites insulating properties. Nanomaterials (Basel) 2018; 8 (06) 381
  • 9 Shuai C, Wang B, Yang Y, Peng S, Gao C. 3D honeycomb nanostructure-encapsulated magnesium alloys with superior corrosion resistance and mechanical properties. Compos, Part B Eng 2019; 162: 611-620
  • 10 Jeon J-G, Rosalen PL, Falsetta ML, Koo H. Natural products in caries research: current (limited) knowledge, challenges and future perspective. Caries Res 2011; 45 (03) 243-263
  • 11 Passos VF, Rodrigues Gerage LK, Lima Santiago S. Magnesium hydroxide-based dentifrice as an anti-erosive agent in an in situ intrinsic erosion model. Am J Dent 2017; 30 (03) 137-141
  • 12 Passos VF, Rodrigues LKA, Santiago SL. The effect of magnesium hydroxide-containing dentifrice using an extrinsic and intrinsic erosion cycling model. Arch Oral Biol 2018; 86: 46-50
  • 13 Naguib GH, Hosny KM, Hassan AH. et al. Zein based magnesium oxide nanoparticles: assessment of antimicrobial activity for dental implications. Pak J Pharm Sci 2018; 31 (1(Suppl.)): 245-250
  • 14 Nurelhuda NM, Al-Haroni M, Trovik TA, Bakken V. Caries experience and quantification of Streptococcus mutans and Streptococcus sobrinus in saliva of Sudanese schoolchildren. Caries Res 2010; 44 (04) 402-407
  • 15 Wang Z, Liu J, Cheng Y. et al. Alignment of boron nitride nanofibers in epoxy composite films for thermal conductivity and dielectric breakdown strength improvement. Nanomaterials (Basel) 2018; 8 (04) 242
  • 16 Slomberg DL, Lu Y, Broadnax AD, Hunter RA, Carpenter AW, Schoenfisch MH. Role of size and shape on biofilm eradication for nitric oxide-releasing silica nanoparticles. ACS Appl Mater Interfaces 2013; 5 (19) 9322-9329
  • 17 Yamamoto O, Fukuda T, Kimata M, Sawai J, Sasamoto T. Antibacterial characteristics of MgO-mounted spherical carbons prepared by carbonization of ion-exchanged resin. J Ceram Soc Jpn 2001; 109 (1268): 363-365
  • 18 Tang Z-X, Lv B-F. MgO nanoparticles as antibacterial agent: preparation and activity. Braz J Chem Eng 2014; 31: 591-601
  • 19 Wassel MO, Khattab MA. Antibacterial activity against Streptococcus mutans and inhibition of bacterial induced enamel demineralization of propolis, miswak, and chitosan nanoparticles based dental varnishes. J Adv Res 2017; 8 (04) 387-392
  • 20 Cai L, Chen J, Liu Z, Wang H, Yang H, Ding W. Magnesium oxide nanoparticles: effective agricultural antibacterial agent against Ralstonia solanacearum. Front Microbiol 2018; 9: 790
  • 21 Fedorov P, Tkachenko E, Kuznetsov S, Voronov V, Lavrishchev S. Preparation of MgO nanoparticles. Inorg Mater 2007; 43 (05) 502-504
  • 22 Sikarwar S, Yadav B. Opto-electronic humidity sensor: A review. Sens Actuators A Phys 2015; 233: 54-70
  • 23 Rodriguez JA, Fernández-García M. Synthesis, properties, and applications of oxide nanomaterials. John Wiley & Sons; 2007
  • 24 Nguyen NT, Grelling N, Wetteland CL, Rosario R, Liu H. Antimicrobial activities and mechanisms of magnesium oxide nanoparticles (nMgO) against pathogenic bacteria, yeasts, and biofilms. Sci Rep 2018; 8 (01) 16260
  • 25 Zhang S, Zhang X, Zhao C. et al. Research on an Mg-Zn alloy as a degradable biomaterial. Acta Biomater 2010; 6 (02) 626-640
  • 26 Patel E, Choonara Y, Pillay V. Dental biomaterials: challenges in the translation from lab to patient. S Afr Dent J 2020; 75 (01) 16-28
  • 27 Bondarenko A, Hewicker-Trautwein M, Erdmann N, Angrisani N, Reifenrath J, Meyer-Lindenberg A. Comparison of morphological changes in efferent lymph nodes after implantation of resorbable and non-resorbable implants in rabbits. Biomed Eng Online 2011; 10 (01) 32
  • 28 Sezer N, Evis Z, Kayhan SM, Tahmasebifar A, Koç M. Review of magnesium-based biomaterials and their applications. Journal of Magnesium and Alloys 2018; 6 (01) 23-43
  • 29 Khalajabadi SZ, Kadir MRA, Izman S, Marvibaigi M. The effect of MgO on the biodegradation, physical properties and biocompatibility of a Mg/HA/MgO nanocomposite manufactured by powder metallurgy method. J Alloys Compd 2016; 655: 266-280
  • 30 Amat NF, Muchtar A, Yahaya N, Ghazali MJ. A review of zirconia as a dental restorative material. Aust J Basic Appl Sci 2012; 6 (12) 9-13
  • 31 Jeevanandam J, Barhoum A, Chan YS, Dufresne A, Danquah MK. Review on nanoparticles and nanostructured materials: history, sources, toxicity and regulations. Beilstein J Nanotechnol 2018; 9 (01) 1050-1074
  • 32 Karimi MA, Haghdar RS, Asadinia R. et al. Synthesis and characterization of nanoparticles and nanocomposite of ZnO and MgO by sonochemical method and their application for zinc polycarboxylate dental cement preparation. Int Nano Lett 2011; 1 (01) 43-51
  • 33 Li Y, Bando Y, Sato T. Preparation of network-like MgO nanobelts on Si substrate. Chem Phys Lett 2002; 359 (1–2): 141-145
  • 34 Karimi MA, Ardakani MM, Asadiniya R, Roozbahani SH. Synthesis and characterization of ZnO and MgO nanoparticles and ZnO/MgO nanocomposite and their application for preparation of zinc phosphate dental cement. Nanosci Nanotech: Ind J. 2010; 4: 11-16
  • 35 Demarco FF, Corrêa MB, Cenci MS, Moraes RR, Opdam NJ. Longevity of posterior composite restorations: not only a matter of materials. Dent Mater 2012; 28 (01) 87-101
  • 36 Wilson N, Lynch CD, Brunton PA. et al. Criteria for the replacement of restorations: Academy of Operative Dentistry European Section. Oper Dent 2016; 41 (S7): S48-S57
  • 37 Sharma D, Sharma S, Kaith BS, Rajput J, Kaur M. Synthesis of ZnO nanoparticles using surfactant free in-air and microwave method. Appl Surf Sci 2011; 257 (22) 9661-9672
  • 38 Mirhosseini M, Afzali M. Investigation into the antibacterial behavior of suspensions of magnesium oxide nanoparticles in combination with nisin and heat against Escherichia coli and Staphylococcus aureus in milk. Food Control 2016; 68: 208-215
  • 39 Makhluf S, Dror R, Nitzan Y, Abramovich Y, Jelinek R, Gedanken A. Microwave-assisted synthesis of nanocrystalline MgO and its use as a bacteriocide. Adv Funct Mater 2005; 15 (10) 1708-1715
  • 40 Naguib G, Hassan A, Al-Hazmi F. et al. Zein based magnesium oxide nanowires: Effect of anionic charge on size, release and stability. Dig J Nanomater Biostruct 2017; 12 (03) 741-749
  • 41 Naguib GH, Nassar HM, Hamed MT. Antimicrobial properties of dental cements modified with zein-coated magnesium oxide nanoparticles. Bioact Mater 2021; 8: 49-56
  • 42 Potdar PD, Jethmalani YD. Human dental pulp stem cells: Applications in future regenerative medicine. World J Stem Cells 2015; 7 (05) 839-851
  • 43 Li TX, Yuan J, Chen Y. et al. Differentiation of mesenchymal stem cells from human umbilical cord tissue into odontoblast-like cells using the conditioned medium of tooth germ cells in vitro. BioMed Res Int 2013; 2013: 218543
  • 44 Zhang W, Yelick PC. Vital pulp therapy-current progress of dental pulp regeneration and revascularization. Int J Dent 2010; 2010: 856087
  • 45 Poggio C, Ceci M, Beltrami R, Dagna A, Colombo M, Chiesa M. Biocompatibility of a new pulp capping cement. Ann Stomatol (Roma) 2014; 5 (02) 69-76
  • 46 Glenske K, Donkiewicz P, Köwitsch A. et al. Applications of metals for bone regeneration. Int J Mol Sci 2018; 19 (03) 826
  • 47 Salem RM, Zhang C, Chou L. Effect of magnesium on dentinogenesis of human dental pulp cells. Int J Biomater 2021; 2021: 6567455
  • 48 Ribeiro DV, de Paula GR, Morelli MR. Effect of water content and MgO/ADP ratio on the properties of magnesium phosphate cement. Mater Res 2020; 23 (03) e20200018
  • 49 Abou Neel E, Bozec L, Perez R, Kim H, Knowles J. Silver nanoparticles as a new generation of antimicrobials. Int J Nanomedicine 2015; 10: 6371-6394
  • 50 Noori AJ, Kareem FA. Setting time, mechanical and adhesive properties of magnesium oxide nanoparticles modified glass-ionomer cement. J Mater Res Technol 2020; 9 (02) 1809-1818
  • 51 Monzavi A, Eshraghi S, Hashemian R, Momen-Heravi F. In vitro and ex vivo antimicrobial efficacy of nano-MgO in the elimination of endodontic pathogens. Clin Oral Investig 2015; 19 (02) 349-356
  • 52 Magalhães AP, Moreira FC, Alves DR. et al. Silver nanoparticles in resin luting cements: Antibacterial and physiochemical properties. J Clin Exp Dent 2016; 8 (04) e415-e422
  • 53 Wang L, Hu C, Shao L. The antimicrobial activity of nanoparticles: present situation and prospects for the future. Int J Nanomedicine 2017; 12: 1227-1249
  • 54 Alam MK, Zheng L, Liu R, Papagerakis S, Papagerakis P, Geyer CR. Synthetic antigen-binding fragments (Fabs) against S. mutans and S. sobrinus inhibit caries formation. Sci Rep 2018; 8 (01) 10173
  • 55 Okada M, Soda Y, Hayashi F. et al. Longitudinal study of dental caries incidence associated with Streptococcus mutans and Streptococcus sobrinus in pre-school children. J Med Microbiol 2005; 54 (Pt 7): 661-665
  • 56 Shkodenko L, Kassirov I, Koshel E. Metal oxide nanoparticles against bacterial biofilms: perspectives and limitations. Microorganisms 2020; 8 (10) 1545
  • 57 Saleem S, Ahmed B, Khan MS, Al-Shaeri M, Musarrat J. Inhibition of growth and biofilm formation of clinical bacterial isolates by NiO nanoparticles synthesized from Eucalyptus globulus plants. Microb Pathog 2017; 111: 375-387
  • 58 Cheng L, Zhang K, Weir MD, Melo MAS, Zhou X, Xu HH. Nanotechnology strategies for antibacterial and remineralizing composites and adhesives to tackle dental caries. Nanomedicine (Lond) 2015; 10 (04) 627-641
  • 59 Debnath A, Kesavappa SB, Singh GP. et al. Comparative evaluation of antibacterial and adhesive properties of chitosan modified glass ionomer cement and conventional glass ionomer cement: an in vitro study. J Clin Diagn Res 2017; 11 (03) ZC75-ZC78