Horm Metab Res 2017; 49(03): 180-184
DOI: 10.1055/s-0043-100116
Endocrine Care
© Georg Thieme Verlag KG Stuttgart · New York

MiR-346 and TRAb as Predicative Factors for Relapse in Graves’ Disease Within One Year

Jianhui Li
1   Department of Endocrine, Ningbo No. 2 Hospital, Ningbo City, Zhejiang Province, China
,
Yawei Cai
2   Department of Geriatrics, Ningbo No. 2 hospital.
,
Xiaohua Sun
1   Department of Endocrine, Ningbo No. 2 Hospital, Ningbo City, Zhejiang Province, China
,
Danzhen Yao
1   Department of Endocrine, Ningbo No. 2 Hospital, Ningbo City, Zhejiang Province, China
,
Jinying Xia
1   Department of Endocrine, Ningbo No. 2 Hospital, Ningbo City, Zhejiang Province, China
› Author Affiliations
Further Information

Publication History

received 29 November 2016

accepted 21 December 2016

Publication Date:
13 February 2017 (online)

Abstract

Despite the efficacy and safety, antithyroid drug (ATD) therapy for Graves’ disease (GD) is associated with a high risk of relapse, especially within the first year. The inability to predict whether and when relapse may occur is a major problem for ATD therapy. This study was aimed to investigate potential predicative factors for GD patients after ATD withdrawal. Consecutive patients newly diagnosed with GD and treated with ATD [methimazole (MMI)] were enrolled in this study. Univariate and multivariate Cox proportional hazard analyses were used for the analysis of predicative parameters for GD relapse after MMI withdrawal. Kaplan-Meier survival analysis and log-rank test were utilized for presenting the risk of relapse. Of the 103 patients included, 67 (65.0%) remained in remission and 36 (35.0%) had a relapse within 1 year after the MMI withdrawal. The multivariate analysis suggested significant predictive factors for GD relapse: patients with higher miR-346 expressions (≥median value) at diagnosis and at cessation, and lower TRAb levels at cessation. MiR-346 at diagnosis and cessation, and TRAb at cessation could serve as predictive factors for GD relapse within 1 year after drug withdrawal.

 
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