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TumorDiagnostik & Therapie 2017; 38(05): 297-301
DOI: 10.1055/s-0043-104005
Schwerpunkt Kopf-Hals-Tumoren
© Georg Thieme Verlag KG Stuttgart · New York

HPV, p16 und die TNM-Klassifikation von Oropharynxkarzinomen

Johannes H. Dreyer
,
Gerald Niedobitek
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Publication Date:
08 June 2017 (online)

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Weltweit weisen zwischen 30 und 80 % der Oropharynxkarzinome eine HPV-Infektion der Tumorzellen auf. HPV-assoziierte Oropharynxkarzinome unterscheiden sich von HPV-negativen Fällen durch einen günstigeren Verlauf. Diesem Umstand versucht die achte Auflage der TNM Klassifikation maligner Tumoren Rechnung zu tragen. Der Nachweis der HPV-Assoziation ist daher zum essentiellen Bestandteil der histopathologischen Diagnostik bei Oropharynxkarzinomen geworden.
 

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