Atopische Dermatitis^[*]

Die atopische Dermatitis ist eine multifaktorielle Hauterkrankung, deren Inzidenz in den letzten Jahrzehnten weltweit zugenommen hat. Die vielfältigen Ursachen der atopischen Dermatitis tragen dazu bei, dass im klinischen Alltag Patienten mit unterschiedlichen klinischen Erscheinungsbildern vorkommen. Diese sind abhängig vom Alter, der Hautbarriere, der Sensibilisierung gegenüber Umweltallergenen und Nahrungsmitteln, dem Zytokinprofil, der Neigung zu Infekten und dem Schweregrad der Erkrankung.

^* Dieser Beitrag wurde erstveröffentlicht in: Kompendium Dermatologie 2016; 1: 20 – 23.

• Literatur

• 1 Bergman KC, Heinrich J, Niemann H. Current status of allergy prevalence in Germany. Allergo J Int 2016; 25: 6-10
• 2 Mortz CG, Andersen KE, Dellgren H. et al. Atopic dermatitis from adolescence to adulthood in the TOACS cohort: prevalence, persistence and comorbidities. Allergy 2015; 70: 836-845
• 3 Irvine AD, McLean WH. Breaking the (un)sound barrier: filaggrin is a major gene for atopic dermatitis. J Invest Dermatol 2006; 126: 1200-1202
• 4 Rodriguez E, Baurecht H, Herberich E. et al. Meta-analysis of filaggrin polymorphisms in eczema and asthma: robust risk factors in atopic disease. J Allergy Clin Immunol 2009; 123: 1361-1370, e1367
• 5 Eyerich K, Novak N. Immunology of atopic eczema: overcoming the Th1/Th2 paradigm. Allergy 2013; 68: 974-982
• 6 Biedermann T, Skabytska Y, Kaesler S. et al. Regulation of T Cell Immunity in Atopic Dermatitis by Microbes: The Yin and Yang of Cutaneous Inflammation. Front Immunol 2015; 6: 353
• 7 Eyerich S, Zielinski CE. Defining Th-cell subsets in a classical and tissue-specific manner: Examples from the skin. Eur J Immunol 2014; Dec; 44: 3475-3483
• 8 Eyerich K, Eyerich S, Biedermann T. The Multi-Modal Immune Pathogenesis of Atopic Eczema. Trends Immunol 2015; 36: 788-801
• 9 Mollanazar NK, Smith PK, Yosipovitch G. Mediators of chronic pruritus in atopic dermatitis: getting the itch out?. Clin Rev Allergy Immunol 2016; 51: 263-292
• 10 Werfel T. et al. S2k guideline on diagnosis and treatment of atopic dermatitis – short version. J Dtsch Dermatol Ges 2016; 14: 92-105
• 11 Quirk SK, Rainwater E, Shure AK. et al. Vitamin D in Atopic Dermatitis, Chronic Urticaria and Allergic Contact Dermatitis. Expert Rev Clin Immunol 2016; 12: 839-847
• 12 Hartmann B, Heine G, Babina M. et al. Targeting the vitamin D receptor inhibits the B cell-dependent allergic immune response. Allergy 2011; 66: 540-548
• 13 Heine G, Tabeling C, Hartmann B. et al. 25-Hydroxvitamin D3 Promotes the Long-Term Effect of Specific Immunotherapy in a Murine Allergy Model. J Immunol 2014; 193: 1017-1023
• 14 Heine G, Hoefer N, Franke A. et al. Association of vitamin D receptor gene polymorphisms with severe atopic dermatitis in adults. Br J Dermatol 2013; 168: 855-858
• 15 Hallau J, Hamann L, Schumann RR. et al. A promoter polymorphism of the Vitamin D metabolism gene cyp24a1 is associated with severe atopic dermatitis in adults. Acta Derm Venerol 2016; 96: 169-172
• 16 Bunikowski R, Mielke ME, Skarabis H. et al. Evidence for a disease-promoting effect of Staphylococcus aureus-derived exotoxins in atopic dermatitis. J Allergy Clin Immunol 2000; 105: 814-819
• 17 Kong HH, Segre JA. Skin microbiome: looking back to move forward. J Invest Dermatol 2012; 132: 933-939
• 18 Thaçi D, Simpson EL, Beck LA. et al. Efficacy and safety of dupilumab in adults with moderate-to-severe atopic dermatitis inadequately controlled by topical treatments: a randomised, placebo-controlled, dose-ranging phase 2b trial. Lancet 2016; 387: 40-52