Pharmacopsychiatry 2017; 50(06): 264-269
DOI: 10.1055/s-0043-113828
Original Paper
© Georg Thieme Verlag KG Stuttgart · New York

Patients’ Knowledge about Prescribed Antipsychotics and Medication Adherence in Schizophrenia: A Cross-Sectional Survey

Nobuhiro Nagai1, Hideaki Tani1, Takefumi Suzuki1, 2, Saeko Ikai1, Philip Gerretsen3, 4, Masaru Mimura1, Hiroyuki Uchida1, 4
  • 1Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan
  • 2Inokashira Hospital, Tokyo, Japan
  • 3Multimodal Imaging Group - Research Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Canada
  • 4Geriatric Psychiatry Division, Centre for Addiction and Mental Health, Toronto, Canada
Further Information

Publication History

Publication Date:
04 July 2017 (eFirst)


Introduction Data on the knowledge about antipsychotic medications prescribed in patients with schizophrenia are very limited. Moreover, it remains unclear how patients’ knowledge about prescribed antipsychotics affects medication adherence.

Methods ighty-one Japanese outpatients with schizophrenia according to the International Classification of Diseases, 10th edition, were included. Patients’ knowledge of the primary antipsychotics prescribed to them in terms of therapeutic effects, type, and implicated neurotransmitters was assessed with a multiple-choice questionnaire developed for this study. Medication possession ratios (MPRs) were compared between patients who answered correctly and those who did not in each category.

Results The percentages of subjects who answered correctly regarding antipsychotic effects, type, and implicated neurotransmitters were low at 30.9%, 30.9%, and 7.4%, respectively. No differences were found in MPRs between subjects who answered correctly and those who did not.

Discussion Our preliminary results indicate that patients lack knowledge about their antipsychotic medications. More concerning, they suggest that knowledge about prescribed antipsychotics may not directly translate into actual medication adherence in patients with schizophrenia.