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Horm Metab Res 2017; 49(09): 647-653
DOI: 10.1055/s-0043-115225
Review
© Georg Thieme Verlag KG Stuttgart · New York

The Effects of Vitamin D Supplementation on Glucose Metabolism and Lipid Profiles in Patients with Gestational Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Maryam Akbari
1   Health Policy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
,
Mahmood Mosazadeh
2   Health Sciences Research Center, Faculty of Health, Mazandaran University of Medical Sciences, Sari, Iran
,
Kamran B. Lankarani
1   Health Policy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
,
Reza Tabrizi
1   Health Policy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
,
Mansooreh Samimi
3   Department of Gynecology and Obstetrics, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran
,
Maryam Karamali
4   Department of Gynecology and Obstetrics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
,
Mehri Jamilian
5   Endocrinology and Metabolism Research Center, Department of Gynecology and Obstetrics, School of Medicine, Arak University of Medical Sciences, Arak, Iran
,
Fariba Kolahdooz
6   Indigenous and Global Health Research, Department of Medicine, University of Alberta, Edmonton, Canada
,
Zatollah Asemi
7   Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran
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Publikationsverlauf

received 08. Februar 2017

accepted 12. Juni 2017

Publikationsdatum:
31. Juli 2017 (online)

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Erratum zu diesem Artikel:

Correction: The Effects of Vitamin D Supplementation on Glucose Metabolism and Lipid Profiles in Patients with Gestational Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled TrialsHorm Metab Res 2017; 49(09): e3-e3
DOI: 10.1055/s-0037-1600933

Abstract

This systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to summarize the effect of vitamin D supplementation on glucose homeostasis parameters and lipid profiles in gestational diabetes (GDM) patients. We conducted an electronic systematic search of MEDLINE, and 4 other research databases from inception to August 2016, in addition to performing hand searches and consulting with experts in the field. The index of heterogeneity between studies was determined using Cochran (Q) and I-squared tests. Given the existing heterogeneity between studies, a fix or random effect model was performed to estimate the standardized mean difference (SMD) for each variable by using inverse variance method and Cohen statistics. Six randomized clinical trials (187 subjects and 184 controls) were included. The results showed that vitamin D supplementation significantly reduced the homeostasis model assessment of insulin resistance (HOMA-IR) [SMD −0.66; 95% confidence interval (CI), −1.14 to −0.18], homeostatic model assessment-B cell function (HOMA-B) (SMD −0.52; 95% CI, −0.79 to −0.25), LDL-cholesterol levels (SMD −0.33; 95% CI, −0.58 to −0.07), and significantly increased quantitative insulin sensitivity check index (QUICKI) (SMD 0.73; 95% CI, 0.26 to 1.20). We found no beneficial effect of vitamin D supplementation on fasting plasma glucose (FPG), insulin, HbA1c, total-, HDL-cholesterol, and triglycerides concentrations. In conclusion, this meta-analysis demonstrated that vitamin D supplementation may lead to an improvement in HOMA-IR, QUICKI, and LDL-cholesterol levels, but did not affect FPG, insulin, HbA1c, triglycerides, total- and HDL-cholesterol levels; however, vitamin D supplementation increased HOMA-B.

Key words

vitamin D - glucose homeostasis - lipid profiles - meta-analysis

Supplementary Material

    Supplementary Material for this article is available online at http://www.thieme-connect.de/products.
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  • References

  • 1 Mishra S, Rao CR, Shetty A. Trends in the diagnosis of gestational diabetes mellitus. Scientifica (Cairo) 2016; 5489015
    PubMedSuche in Google Scholar
  • 2 Mpondo BC, Ernest A, Dee HE. Gestational diabetes mellitus: Challenges in diagnosis and management. J Diabetes Metab Disord 2015; 14: 42
    CrossrefPubMedSuche in Google Scholar
  • 3 Garrison A. Screening, diagnosis, and management of gestational diabetes mellitus. Am Fam Physician 2015; 91: 460-467
    PubMedSuche in Google Scholar
  • 4 Perez-Mendez O, Pacheco HG, Martinez-Sanchez C, Franco M. HDL-cholesterol in coronary artery disease risk: Function or structure?. Clin Chim Acta 2014; 429: 111-122
    CrossrefPubMedSuche in Google Scholar
  • 5 Sanchez-Vera I, Bonet B, Viana M, Quintanar A, Martin MD, Blanco P, Donnay S, Albi M. Changes in plasma lipids and increased low-density lipoprotein susceptibility to oxidation in pregnancies complicated by gestational diabetes: Consequences of obesity. Metabolism 2007; 56: 1527-1533
    CrossrefPubMedSuche in Google Scholar
  • 6 Garrison EA, Jagasia S. Inpatient management of women with gestational and pregestational diabetes in pregnancy. Curr Diab Rep 2014; 14: 457
    CrossrefPubMedSuche in Google Scholar
  • 7 Muthukrishnan J, Dhruv G. Vitamin D status and gestational diabetes mellitus. Indian J Endocrinol Metab 2015; 19: 616-619
    CrossrefPubMedSuche in Google Scholar
  • 8 Pleskacova A, Bartakova V, Pacal L, Kuricova K, Belobradkova J, Tomandl J, Kankova K. Vitamin D status in women with gestational diabetes mellitus during pregnancy and postpartum. Biomed Res Int 2015; 260624
    PubMedSuche in Google Scholar
  • 9 Meinila J, Koivusalo SB, Valkama A, Rono K, Erkkola M, Kautiainen H, Stach-Lempinen B, Eriksson JG. Nutrient intake of pregnant women at high risk of gestational diabetes. Food Nutr Res 2015; 59: 26676
    PubMedSuche in Google Scholar
  • 10 Verburg PE, Tucker G, Scheil W, Erwich JJ, Dekker GA, Roberts CT. Seasonality of gestational diabetes mellitus: A South Australian population study. BMJ Open Diabetes Res Care 2016; 4: e000286
    PubMedSuche in Google Scholar
  • 11 Asemi Z, Hashemi T, Karamali M, Samimi M, Esmaillzadeh A. Effects of vitamin D supplementation on glucose metabolism, lipid concentrations, inflammation, and oxidative stress in gestational diabetes: A double-blind randomized controlled clinical trial. Am J Clin Nutr 2013; 98: 1425-1432
    CrossrefPubMedSuche in Google Scholar
  • 12 Yazdchi R, Gargari BP, Asghari-Jafarabadi M, Sahhaf F. Effects of vitamin D supplementation on metabolic indices and hs-CRP levels in gestational diabetes mellitus patients: A randomized, double-blinded, placebo-controlled clinical trial. Nutr Res Pract 2016; 10: 328-335
    CrossrefPubMedSuche in Google Scholar
  • 13 Yap C, Cheung NW, Gunton JE, Athayde N, Munns CF, Duke A, McLean M. Vitamin D supplementation and the effects on glucose metabolism during pregnancy: a randomized controlled trial. Diabetes Care 2014; 37: 1837-1844
    CrossrefPubMedSuche in Google Scholar
  • 14 Yeow TP, Lim SL, Hor CP, Khir AS, Wan Mohamud WN, Pacini G. Impact of Vitamin D Replacement on Markers of Glucose Metabolism and Cardio-Metabolic Risk in Women with Former Gestational Diabetes–A Double-Blind, Randomized Controlled Trial. PLoS One 2015; 10: e0129017
    CrossrefPubMedSuche in Google Scholar
  • 15 Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJ, Gavaghan DJ, McQuay HJ. Assessing the quality of reports of randomized clinical trials: is blinding necessary?. Control Clin Trials 1996; 17: 1-12
    CrossrefPubMedSuche in Google Scholar
  • 16 Li J, Liu Z, Chen R, Hu D, Li W, Li X, Chen X, Huang B, Liao L. The quality of reports of randomized clinical trials on traditional Chinese medicine treatments: A systematic review of articles indexed in the China National Knowledge Infrastructure database from 2005 to 2012. BMC Complement Altern Med 2014; 14: 362
    CrossrefPubMedSuche in Google Scholar
  • 17 Asemi Z, Karamali M, Esmaillzadeh A. Effects of calcium-vitamin D co-supplementation on glycaemic control, inflammation and oxidative stress in gestational diabetes: A randomised placebo-controlled trial. Diabetologia 2014; 57: 1798-1806
    CrossrefPubMedSuche in Google Scholar
  • 18 Jamilian M, Karamali M, Taghizadeh M, Sharifi N, Jafari Z, Memarzadeh MR, Mahlouji M, Asemi Z. Vitamin D and evening primrose oil administration improve glycemia and lipid profiles in women with gestational diabetes. Lipids 2016; 51: 349-356
    CrossrefPubMedSuche in Google Scholar
  • 19 Mozaffari-Khosravi H, Hosseinzadeh-Shamsi-Anar M, Salami MA, Hadinedoushan H, Mozayan MR. Effects of a single post-partum injection of a high dose of vitamin D on glucose tolerance and insulin resistance in mothers with first-time gestational diabetes mellitus. Diabet Med 2012; 29: 36-42
    CrossrefPubMedSuche in Google Scholar
  • 20 Valizadeh M, Piri Z, Mohammadian F, Kamali K, Moghadami HRA. The impact of vitamin D supplementation on post-partum glucose tolerance and insulin resistance in gestational diabetes: A randomized controlled trial. Int J Endocrinol Metab 2016; 14: e34312
    PubMedSuche in Google Scholar
  • 21 Asemi Z, Karamali M, Esmaillzadeh A. Favorable effects of vitamin D supplementation on pregnancy outcomes in gestational diabetes: A double blind randomized controlled clinical trial. Horm Metab Res 2015; 47: 565-570
    Thieme ConnectPubMedSuche in Google Scholar
  • 22 Langer J, Penna-Martinez M, Bon D, Herrmann E, Wallasch M, Badenhoop K. Insufficient Vitamin D response to solar radiation in german patients with type 2 diabetes or gestational diabetes. Horm Metab Res 2016; 48: 503-508
    Thieme ConnectPubMedSuche in Google Scholar
  • 23 Serra MC, Ryan AS. Influence of Vitamin D and Parathyroid hormone on bone and metabolic risk in women with previous gestational diabetes. Horm Metab Res 2016; 48: 497-502
    Thieme ConnectPubMedSuche in Google Scholar
  • 24 Zhang MX, Pan GT, Guo JF, Li BY, Qin LQ, Zhang ZL. Vitamin D deficiency increases the risk of gestational diabetes mellitus: A meta-analysis of observational studies. Nutrients 2015; 7: 8366-8375
    CrossrefPubMedSuche in Google Scholar
  • 25 Sarathy H, Pramanik V, Kahn J, Abramowitz MK, Meier K, Kishore P, Melamed ML. The effects of short-term vitamin D supplementation on glucose metabolism in dialysis patients: A systematic review and meta-analysis. Int Urol Nephrol 2015; 47: 537-549
    CrossrefPubMedSuche in Google Scholar
  • 26 Perez-Lopez FR, Pasupuleti V, Mezones-Holguin E, Benites-Zapata VA, Thota P, Deshpande A, Hernandez AV. Effect of vitamin D supplementation during pregnancy on maternal and neonatal outcomes: A systematic review and meta-analysis of randomized controlled trials. Fertil Steril 2015; 103: 1278-1288
    CrossrefPubMedSuche in Google Scholar
  • 27 Autier P, Boniol M, Pizot C, Mullie P. Vitamin D status and ill health: A systematic review. Lancet Diabetes Endocrinol 2014; 2: 76-89
    CrossrefPubMedSuche in Google Scholar
  • 28 Law MR, Wald NJ, Rudnicka AR. Quantifying effect of statins on low density lipoprotein cholesterol, ischaemic heart disease, and stroke: Systematic review and meta-analysis. BMJ 2003; 326: 1423
    CrossrefPubMedSuche in Google Scholar
  • 29 Grundy SM, Cleeman JI, Merz CN, Brewer Jr. HB, Clark LT, Hunninghake DB, Pasternak RC, Smith Jr. SC, Stone NJ. Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines. Circulation 2004; 110: 227-239
    CrossrefPubMedSuche in Google Scholar
  • 30 Delahoy PJ, Magliano DJ, Webb K, Grobler M, Liew D. The relationship between reduction in low-density lipoprotein cholesterol by statins and reduction in risk of cardiovascular outcomes: an updated meta-analysis. Clin Ther 2009; 31: 236-244
    CrossrefPubMedSuche in Google Scholar
  • 31 Kelishadi R, Farajzadegan Z, Bahreynian M. Association between vitamin D status and lipid profile in children and adolescents: A systematic review and meta-analysis. Int J Food Sci Nutr 2014; 65: 404-410
    CrossrefPubMedSuche in Google Scholar
  • 32 Jorde R, Figenschau Y, Hutchinson M, Emaus N, Grimnes G. High serum 25-hydroxyvitamin D concentrations are associated with a favorable serum lipid profile. Eur J Clin Nutr 2010; 64: 1457-1464
    CrossrefPubMedSuche in Google Scholar
  • 33 Manousopoulou A, Al-Daghri NM, Garbis SD, Chrousos GP. Vitamin D and cardiovascular risk among adults with obesity: A systematic review and meta-analysis. Eur J Clin Invest 2015; 45: 1113-1126
    CrossrefPubMedSuche in Google Scholar
  • 34 Wang H, Xia N, Yang Y, Peng DQ. Influence of vitamin D supplementation on plasma lipid profiles: A meta-analysis of randomized controlled trials. Lipids Health Dis 2012; 11: 42
    CrossrefPubMedSuche in Google Scholar
  • 35 Kaplan M, Kerry R, Aviram M, Hayek T. High glucose concentration increases macrophage cholesterol biosynthesis in diabetes through activation of the sterol regulatory element binding protein 1 (SREBP1): inhibitory effect of insulin. J Cardiovasc Pharmacol 2008; 52: 324-332
    CrossrefPubMedSuche in Google Scholar