Int J Sports Med 2018; 39(01): 73-78
DOI: 10.1055/s-0043-118033
Immunology
© Georg Thieme Verlag KG Stuttgart · New York

Resting Autonomic Function in Active and Insufficiently Active People Living with HIV

Norberto Quiles
1  Queens College, Family, Nutrition and Exercise Science, Flushing, United States
,
Carol Garber
2  Biobehavioral Sciences, Teachers College of Columbia University, New York, United States
,
Joseph Ciccolo
2  Biobehavioral Sciences, Teachers College of Columbia University, New York, United States
› Author Affiliations
Further Information

Publication History



accepted after revision 24 July 2017

Publication Date:
21 November 2017 (eFirst)

Abstract

Autonomic dysfunction appears to be prevalent in people living with HIV/AIDS (PLWHA). However, there are limited data on the resting autonomic responses to exercise in active and insufficiently active PLWHA. We aimed to determine whether active PLWHA have better autonomic responses compared with insufficiently active PLWHA. Active PLWHA receiving anti-retroviral therapy (n=13) and insufficiently active PLWHA (n=10) were recruited. A 10-min recording of the supine electrocardiogram was taken. Resting heart rate variability was analyzed from this electrocardiogram. Parasympathetic modulation, as measured by high frequency power in normalized units, was greater in active PLWHA when compared to insufficiently active PLWHA (41.0±15.6 vs. 25.2±9.7; p<0.05). Sympathetic modulation as measured by low frequency power in normalized units was greater in insufficiently active PLWHA when compared to active PLWHA (55.6±15.8 vs 79.3±17.5; p<0.05). Sympathovagal balance as measured by low frequency/high frequency ratio was greater in insufficiently active PLWHA when compared to active PLWHA (3.4±1.8 vs 1.6±0.9; p<0.05), indicating greater parasympathetic dominance in the active group. In conclusion, PLWHA who regularly exercised demonstrated enhanced autonomic function compared with insufficiently active PLWHA. These results suggest that exercise is associated with enhanced autonomic function, and may improve cardiovascular risk.