Int J Sports Med 2018; 39(02): 83-88
DOI: 10.1055/s-0043-118848
Physiology & Biochemistry
© Georg Thieme Verlag KG Stuttgart · New York

Oxidized Low-Density Lipoprotein and Cell Adhesion Molecules Following Exercise Training

Yunsuk Koh
Health, Human Performance, and Recreation, Baylor University, Waco, United States
Jin Park
Northern VA Community College, 21200 Campus Dr., Sterling, United States
Rick Carter
Health and Kinesiology, Lamar University, Beaumont, United States
› Author Affiliations
Further Information

Publication History

accepted after revision 14 August 2017

Publication Date:
30 November 2017 (eFirst)


Elevated oxidized low-density lipoprotein (ox-LDL) and cell adhesion molecules are associated with inflammation and atherosclerosis. The role of exercise in circulating ox-LDL, enzyme mediators, and cell adhesion molecules are not clearly understood in obesity. As a randomized controlled design, 27 obese (BMI>30 kg/m2) sedentary men (N=13) and women (N=14) were randomly assigned to either an exercise (N=15) or a control (N=12) group. The exercise group performed a 60-min supervised treadmill exercise at moderate intensity (70% of HRmax) for 3 days per week for 4 weeks, while the control group did not exercise. Overnight fasting blood samples were collected before and after the study period to analyze serum lipids, lipoprotein-cholesterol, ox-LDL, 12- and 15-lipoxygenases, myeloperoxidase (MPO), and soluble vascular cell adhesion molecules-1 and intercellular adhesion molecule-1. Moderate-intensity exercise training lowered both ox-LDL (from 44.76±1.99 to 38.51±1.99 U/L, p=0.032) and MPO (from 31.48±2.20 to 23.09±2.20 ng/mL, p=0.010), without significantly altering body weight, other parameters of serum lipids and lipoproteins, or soluble cell adhesion molecules. Moderate intensity exercise training reduced the levels of ox-LDL and MPO, indicating a reduced risk for developing CVD and additional protection to the possible metabolic complications associated with obesity.