Dtsch Med Wochenschr 2018; 113(13): 970-978
DOI: 10.1055/s-0043-120839
Übersicht
© Georg Thieme Verlag KG Stuttgart · New York

Chemotherapie-induzierte periphere Neuropathie

Peripheral neuropathy as a side effect of chemotherapy and targeted therapy
Clemens Gießen-Jung
,
Louisa von Baumgarten
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
04. Juli 2018 (online)

Abstract

Chemotherapy-induced peripheral neuropathy (CIPN) is a severe and common side effect induced by a variety of anticancer drugs. CIPN presents as a sensory, motor, and sometimes autonomic dysfunction with a large variability, from a mild tingling sensation and hyperesthesia, to severe neuropathic pain. Up to 40 % of patients will develop CIPN which may lead to dose-reduction or discontinuation of their current treatment and largely affects their quality of life (QoL). This review presents specific clinical features and pathomechanisms and discusses current preventive strategies and therapeutic options.

Die Chemotherapie-induzierte periphere Neuropathie (CIPN) ist eine häufige Nebenwirkung bei antineoplastischen Therapien mit substanzspezifischer Varianz. Auch zielgerichtete Substanzen können zur CIPN führen, was ein relevantes klinisches Problem darstellt, da dies häufig zu Dosisreduktion oder gar zum Abbruch der Behandlung führt. Dieser Beitrag gibt eine Übersicht über Pathophysiologie, klinische Symptomatik, Diagnostik und Therapieoptionen.

 
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