Int J Sports Med 2018; 39(03): 181-188
DOI: 10.1055/s-0043-123647
Physiology & Biochemistry
© Georg Thieme Verlag KG Stuttgart · New York

Response of Cerebral Blood Flow and Blood Pressure to Dynamic Exercise: A Study Using PET

Mikio Hiura
1  Faculty of Sports and Health Studies, Hosei University, Tokyo, Japan
,
Tadashi Nariai
2  Department of Neurosurgery, Tokyo Ika Shika Daigaku, Bunkyo-ku, Japan
,
Muneyuki Sakata
3  Tokyo-to Kenko Choju Iryo Center, Research Team for Neuroimaging, Itabashi-ku, Japan
,
Akitaka Muta
2  Department of Neurosurgery, Tokyo Ika Shika Daigaku, Bunkyo-ku, Japan
,
Kenji Ishibashi
3  Tokyo-to Kenko Choju Iryo Center, Research Team for Neuroimaging, Itabashi-ku, Japan
,
Kei Wagatsuma
3  Tokyo-to Kenko Choju Iryo Center, Research Team for Neuroimaging, Itabashi-ku, Japan
,
Tetsuro Tago
3  Tokyo-to Kenko Choju Iryo Center, Research Team for Neuroimaging, Itabashi-ku, Japan
,
Jun Toyohara
3  Tokyo-to Kenko Choju Iryo Center, Research Team for Neuroimaging, Itabashi-ku, Japan
,
Kenji Ishii
3  Tokyo-to Kenko Choju Iryo Center, Research Team for Neuroimaging, Itabashi-ku, Japan
,
Taketoshi Maehara
2  Department of Neurosurgery, Tokyo Ika Shika Daigaku, Bunkyo-ku, Japan
› Author Affiliations
Further Information

Publication History



accepted 05 November 2017

Publication Date:
22 January 2018 (eFirst)

Abstract

Dynamic exercise elicits fluctuations in blood pressure (BP) and cerebral blood flow (CBF). This study investigated responses in BP and CBF during cycling exercise and post-exercise hypotension (PEH) using positron emission tomography (PET). CBF was measured using oxygen-15-labeled water (H2 15O) and PET in 11 human subjects at rest (Rest), at the onset of exercise (Ex1), later in the exercise (Ex2), and during PEH. Global CBF significantly increased by 13% at Ex1 compared with Rest, but was unchanged at Ex2 and during PEH. Compared with at Rest, regional CBF (rCBF) increased at Ex1 (20~42%) in the cerebellar vermis, sensorimotor cortex for the bilateral legs (M1Leg and S1Leg), insular cortex and brain stem, but increased at Ex2 (28~31%) only in the vermis and M1Leg and S1Leg. During PEH, rCBF decreased compared with Rest (8~13%) in the cerebellum, temporal gyrus, piriform lobe, thalamus and pons. The areas showing correlations between rCBF and mean BP during exercise and PEH were consistent with the central autonomic network, including the brain stem, cerebellum, and hypothalamus (R2=0.25–0.64). The present study suggests that higher brain regions are coordinated through reflex centers in the brain stem in order to regulate the cardiovascular response to exercise.