Primary Localized Cutaneous Nodular Amyloidosis of the Cheeks

Abstract

We report the rare case of a primary localized cutaneous nodular amyloidosis (PLCNA), which clinically appeared as waxy, yellow-red infiltrated plaques with telangiectasia on the face of a 52-year-old woman. Diagnosis was confirmed by immunohistochemistry results. Histologically, diffuse amyloid tissue infiltration could be revealed. Amyloid stained positive for lambda, but negative for kappa light chain antibodies whereas no proliferation of clonal plasma cells in the bone marrow was found.

Zusammenfassung

Wir berichten über den seltenen Fall einer primär lokalisierten kutanen nodulären Amyloidose (PLNCA), die sich wachsartig mit gelb-rot infiltrierten Plaques an der Gesichtshaut einer 52-jährigen Frau zeigte. Die Diagnose wurde immunhistochemisch bestätigt. Es fand sich eine diffuse Amyloid-Infiltration mit positiver Färbung für Lambda- und negativer für Kappa-Leichtketten-Antikörper ohne Proliferation der klonalen Plasmazellen ins Knochenmark.

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