Highly Efficient and Practical Oxidative Bromination of Electron-Rich Arenes Using S-Methyl Methanethiosulfonate as the Oxidant

Shaolong Wang; Yong Zhou; Jianbo Wang; Ruolan Li; Chaoqun Huang; Huailin Pang; Xun Li

doi:10.1055/s-0043-1763752

Synlett, Table of Contents

Synlett 2025; 36(01): 87-91
DOI: 10.1055/s-0043-1763752

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Highly Efficient and Practical Oxidative Bromination of Electron-Rich Arenes Using S-Methyl Methanethiosulfonate as the Oxidant

Authors

Shaolong Wang

^aSchool of Chemistry and Chemical Engineering, Changsha University of Science and Technology, Changsha, 960 2nd Section Wanjiali Road, Hunan 410114, P. R. of China
Yong Zhou

^bJiangxi Tianyu Chemical Co., Ltd., North Salt Chemical Industrial City, Ji'an, Jiangxi 331300 , P. R. of China
Jianbo Wang

^aSchool of Chemistry and Chemical Engineering, Changsha University of Science and Technology, Changsha, 960 2nd Section Wanjiali Road, Hunan 410114, P. R. of China
Ruolan Li

^cHunan Normal University, College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha, No. 36 Lushan Road, Hunan 410081, P. R. of China
Chaoqun Huang

^bJiangxi Tianyu Chemical Co., Ltd., North Salt Chemical Industrial City, Ji'an, Jiangxi 331300 , P. R. of China
Huailin Pang

^bJiangxi Tianyu Chemical Co., Ltd., North Salt Chemical Industrial City, Ji'an, Jiangxi 331300 , P. R. of China
Xun Li∗

^aSchool of Chemistry and Chemical Engineering, Changsha University of Science and Technology, Changsha, 960 2nd Section Wanjiali Road, Hunan 410114, P. R. of China

Abstract

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Abstract

An efficient and practical method for the bromination of electron-rich arenes and heteroarenes was developed by using S-methyl methanethiosulfonate as the oxidant. All the bromine atoms were basically transferred to the brominated products, demonstrating the exceptional atom economy and practicality of the proposed protocol. The method reduces the amount of bromine required for this reaction system and obtains products in moderate to good yields.

Key words

bromination - aromatic ring - S-methyl methanethiosulfonate - regioselective - oxidation

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References

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Supplementary Material

Supporting Information (PDF)