CC BY-NC-ND 4.0 · Ibnosina Journal of Medicine and Biomedical Sciences 2023; 15(01): 005-019
DOI: 10.1055/s-0043-1764355
Review Article

Burden and Patterns of Medical Emergencies during Ramadan Fasting: A Narrative Review

1   Department of Gastroenterology, Wythenshawe Hospital, Manchester, United Kingdom
,
Jamila S. Elamouri
2   Nephrology Unit, Department of Internal Medicine, Tripoli Central Hospital, Tripoli, Libya
,
3   Department of Medicine, Sheikh Khalifa Medical City, SEHA, Abu Dhabi, United Arab Emirates
,
Husen Abdulrahman
3   Department of Medicine, Sheikh Khalifa Medical City, SEHA, Abu Dhabi, United Arab Emirates
,
4   Department of Medicine, Rashid Hospital, Dubai Health Authority, Dubai, United Arab Emirates
5   Department of Medicine, Dubai Medical College for Girls, Dubai, United Arab Emirates
,
5   Department of Medicine, Dubai Medical College for Girls, Dubai, United Arab Emirates
6   Department of Medicine, College of Medicine and Health Sciences, Khalifa University, Abu Dhabi, United Arab Emirates
7   Department of Medicine, Yas Clinic Khalifa City, Abu Dhabi, United Arab Emirates
› Author Affiliations
Funding and Sponsorship None.

Abstract

Introduction Acute medical problems may occur more frequently during Ramadan fasting (RF). We aimed to provide a narrative overview of the global literature on medical emergencies during RF.

Methods This is a nonsystematic review of the international literature from one major medical online database (PubMed, National Institutes of Health, United States). The relevant literature was narrated in a concise thematic account.

Results There is a variable impact in the burden and time distribution of emergency services and hospitalization during RF that may require readjustment of resource allocation. Studies of the risk of accidents and injuries may be increased overall or at specified times, around Iftar time. A classical impact of emergencies has been the risk of worsening peptic ulcer disease. RF impacts diabetic emergencies such as severe hypoglycemia, hyperglycemia, and diabetic ketoacidosis, particularly in type 1 diabetes and poorly controlled patients. Glucocorticoid replacement therapy may represent a challenge to patients and physicians that require education and dose adjustment. Acute neurological conditions of interest include the “first day of Ramadan headache,” epilepsy, and strokes. Several studies evaluated the risk of the acute coronary syndrome and heart failure with inconsistent findings. RF may impact the renal and urological systems through stone disease, renal colic, and acute kidney. The impact on hematological conditions was mostly focused on the safety of anticoagulant therapy during Ramadan.

Conclusion The review addresses the emergency medical encounters of the fasting patient during Ramadan to allow a holistic and ethnically sensitive approach to medical care under circumstances where decisions have to be taken with no delay.

Author Contributions

The authors contributed equally to the manuscript's conception, drafting, and revision. All authors reviewed and approved the final version.


Compliance with Ethical Principles

Ethical approval is not required for review types of studies.




Publication History

Article published online:
17 March 2023

© 2023. The Libyan Biotechnology Research Center. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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  • References

  • 1 Beshyah WS, Beshyah SA. Bibliometric analysis of the literature on Ramadan fasting and diabetes in the past three decades (1989-2018). Diabetes Res Clin Pract 2019; 151: 313-322
  • 2 Beshyah SA, Fathalla W, Saleh A. et al. Ramadan fasting and the medical patient: an overview for clinicians. Ibnosina J Med Biomed Sci. 2010; 2 (05) 240-257
  • 3 Obaideen K, Abu Shihab KH, Madkour MI, Faris ME. Seven decades of Ramadan intermittent fasting research: bibliometrics analysis, global trends, and future directions. Diabetes Metab Syndr 2022; 16 (08) 102566
  • 4 Leca A, Fortesa L. Greater incidence of perforated peptic ulcers in the Ramadan period [in French]. Afr Fr Chir 1954; 12 (06) 577-578
  • 5 Lahbabi H. [Significance of the frequency of perforated ulcer during the Ramadan]. Maroc Med 1957; 36 (384) 449-450
  • 6 Vach B. Perforation of gastroduodenal ulcer among the population of Tunis. Effect of the Ramadan on the frequency of perforations [in Czech]. Rozhl Chir 1966; 45 (05) 300-304
  • 7 Langford EJ, Ishaque MA, Fothergill J, Touquet R. The effect of the fast of Ramadan on accident and emergency attendances. J R Soc Med 1994; 87 (09) 517-518
  • 8 Parrilla Ruiz F, Cárdenas Cruz DP, Vargas Ortega DA, Cárdenas Cruz A. El ayuno del Ramadán y una unidad de urgencias. [The Ramadan fast and an emergency unit] Aten Primaria 2003; 32 (01) 61-63
  • 9 Topacoglu H, Karcioglu O, Yuruktumen A. et al. Impact of Ramadan on demographics and frequencies of disease-related visits in the emergency department. Int J Clin Pract 2005; 59 (08) 900-905
  • 10 Pekdemir M, Ersel M, Yilmaz S, Uygun M. No significant alteration in admissions to emergency departments during Ramadan. J Emerg Med 2010; 38 (02) 253-256
  • 11 Halasa W. Effect of Ramadan fasting on emergency walk-in-clinics in Jordan. Br J Gen Pract 2014; 64 (625) 388
  • 12 Al Assaad RG, Bachir R, El Sayed MJ. Impact of Ramadan on emergency department visits and on medical emergencies. Eur J Emerg Med 2018; 25 (06) 440-444
  • 13 Balhara KS, Levin S, Cole G. et al. Emergency department resource utilization during Ramadan: distinct and reproducible patterns over a 4-year period in Abu Dhabi. Eur J Emerg Med 2018; 25 (01) 39-45
  • 14 Thomas SA, Bashir K, Jenkins DW, Pathan SA, Thomas SH. Ramadan-associated circadian census variation in a busy Middle Eastern emergency department. J Ayub Med Coll Abbottabad 2019; 31 (04) 586-592
  • 15 Saleh R, Makki M, Tamim H, Hitti E. The impact of Ramadan on patient attendance patterns in an emergency department at a tertiary care center in Beirut, Lebanon. J Emerg Med 2020; 59 (05) 720-725
  • 16 Faruqi I, Mazrouei LA, Buhumaid R. Impact of Ramadan on emergency department patients flow; a cross-sectional study in UAE. Adv J Emerg Med 2020; 4 (02) e22
  • 17 Butt T, Khan HU, Ahmed I, Eldali A. Emergency department attendance patterns during Ramadan. Ann Saudi Med 2016; 36 (04) 258-264
  • 18 Ben Saida I, Kallel H, Chaouch S, Toumi R, Zarrougui W, Boussarsar M. Impacts of Ramadan on intensive care unit admission patterns and outcomes. Tunis Med 2019; 97 (10) 1153-1159
  • 19 Kayipmaz AE, Celikel E, Kavalci C, Ozbay S, Coskun A. The duration of fasting in Ramadan affects the admissions to emergency department. Eurasian J Emerg Med 2018; 17 (04) 178-181
  • 20 Sawaya RD, Wakil C, Shayya S. et al. Pediatric emergency department utilisation during Ramadan: a retrospective cross-sectional study. Arch Dis Child 2021; 106 (03) 272-275
  • 21 Bener A, Absood GH, Achan NV, Sankaran-Kutty M. Road traffic injuries in Al-Ain City, United Arab Emirates. J R Soc Health 1992; 112 (06) 273-276
  • 22 Mehmood A, Khan IQ, Mir MU, Moin A, Jooma R. Vulnerable road users are at greater risk during Ramadan – results from road traffic surveillance data. J Pak Med Assoc 2015; 65 (03) 287-291
  • 23 Tahir MN, Macassa G, Akbar AH, Naseer R, Zia A, Khan S. Road traffic crashes in Ramadan: an observational study. East Mediterr Health J 2014; 19 (Suppl. 03) S147-S151
  • 24 Akman C, Kuru T. Analysis of emergency department presentations due to injuries from motor vehicle crashes and pedestrian strikes. Cureus 2020; 12 (07) e9468
  • 25 Ghumman U, Horney J. Characterizing the impact of extreme heat on mortality, Karachi, Pakistan, June 2015. Prehosp Disaster Med 2016; 31 (03) 263-266
  • 26 Khammash MR, Al-Shouha TF. Do road traffic accidents increase during the fasting month of Ramadan. Neurosciences (Riyadh) 2006; 11 (01) 21-23
  • 27 Göçmen E, Koç M, Tez M, Yoldaş O, Bilgin A, Keşkek M. Effect of Ramadan on surgical emergencies. Ann Emerg Med 2004; 44 (03) 283-285
  • 28 Husseiny AM, El-Sayed MA, Eshra A, Al-Meshaan M. The effect of Ramadan fasting on surgical emergency attendants. Kuwait Med J 2008; 40 (02) 124-126
  • 29 AlZahrani AM, Zawawi MM, Almutairi NA, Alansari AY, Bargawi AA. The impact of Ramadan on visits related to diabetes emergencies at a tertiary care center. BMC Emerg Med 2021; 21 (01) 162
  • 30 Tong CV, Yow HY, Mohd Noor N, Hussein Z. DEARS (Diabetes Emergencies Around Ramadan Study) study group. Diabetes emergencies around Ramadan study (DEARS) - A multi-center study of diabetes emergencies admitted before, during and after Ramadan in Malaysia. Diabetes Res Clin Pract 2021; 175: 108854
  • 31 Elbarsha A, Elhemri M, Lawgaly SA, Rajab A, Almoghrabi B, Elmehdawia RR. Outcomes and hospital admission patterns in patients with diabetes during Ramadan versus a non-fasting period. Ann Saudi Med 2018; 38 (05) 344-351
  • 32 Salti I, Bénard E, Detournay B. et al; EPIDIAR study group. A population-based study of diabetes and its characteristics during the fasting month of Ramadan in 13 countries: results of the epidemiology of diabetes and Ramadan 1422/2001 (EPIDIAR) study. Diabetes Care 2004; 27 (10) 2306-2311
  • 33 Beshyah SA, Hassanein M, Ahmedani MY. et al. Diabetic hypoglycaemia during Ramadan fasting: a trans-national observational real-world study. Diabetes Res Clin Pract 2019; 150: 315-321
  • 34 Al Sifri S, Basiounny A, Echtay A. et al; 2010 Ramadan Study Group. The incidence of hypoglycaemia in Muslim patients with type 2 diabetes treated with sitagliptin or a sulphonylurea during Ramadan: a randomised trial. Int J Clin Pract 2011; 65 (11) 1132-1140
  • 35 Mohamed K, Al-Abdulrazzaq D, Fayed A. et al. Fasting during the holy month of Ramadan among older children and adolescents with type 1 diabetes in Kuwait. J Pediatr Endocrinol Metab 2019; 32 (08) 843-849
  • 36 Beshyah AS, Beshyah SA. The incidence of diabetic ketoacidosis during Ramadan fasting: a 10-year single-centre retrospective study. Diabetes Res Clin Pract 2019; 150: 296-300
  • 37 Alshahrani M, Alraddadi A. Incidence of diabetic ketoacidosis during Ramadan compared with non-fasting months in King Saud Medical City, Riyadh, Saudi Arabia. J Family Med Prim Care 2022; 11 (07) 3905-3908
  • 38 Beshyah SA, Chowdhury TA, Ghouri N, Lakhdar AA. Risk of diabetic ketoacidosis during Ramadan fasting: a critical reappraisal. Diabetes Res Clin Pract 2019; 151: 290-298
  • 39 Elamari S, Elaziz S, Chadli A, Farouqi A. Management of diabetes during Ramadan fasting: applications of international recommendations in clinical practice [in French]. Pan Afr Med J 2020; 36: 316
  • 40 Loh HH, Lim LL, Loh HS, Yee A. Safety of Ramadan fasting in young patients with type 1 diabetes: a systematic review and meta-analysis. J Diabetes Investig 2019; 10 (06) 1490-1501
  • 41 Beshyah SA, Fiad TM, Saadi HF. Management of common endocrine conditions other than diabetes mellitus during Ramadan fasting. Ibnosina J Med BS 2012; 4 (04) 137-146
  • 42 Chihaoui M, Chaker F, Yazidi M. et al. Ramadan fasting in patients with adrenal insufficiency. Endocrine 2017; 55 (01) 289-295
  • 43 Hussain S, Hussain S, Mohammed R, Meeran K, Ghouri N. Fasting with adrenal insufficiency: practical guidance for healthcare professionals managing patients on steroids during Ramadan. Clin Endocrinol (Oxf) 2020; 93 (02) 87-96
  • 44 Chihaoui M, Yazidi M, Oueslati I, Khessairi N, Chaker F. Intermittent fasting in adrenal insufficiency patients: a review and guidelines for practice. Endocrine 2021; 74 (01) 11-19
  • 45 Betesh-Abay B, Shiyovich A, Davidian S, Gilutz H, Shalata W, Plakht Y. The Association between acute myocardial infarction-related outcomes and the Ramadan period: a retrospective population-based study. J Clin Med 2022; 11 (17) 5145
  • 46 Sriha Belguith A, Baccouche H, Grissa MH. et al. The risk of acute coronary syndrome in Ramadan. Tunis Med 2016; 94 (8-9): 599-603
  • 47 Temizhan A, Dönderici O, Ouz D, Demirbas B. Is there any effect of Ramadan fasting on acute coronary heart disease events?. Int J Cardiol 1999; 70 (02) 149-153
  • 48 Raffee LA, Alawneh KZ, Al Suleiman MK, Ibdah RK, Rawashdeh SI, Al-Mistarehi AW. An observational study of the occurrence of acute coronary syndrome (ACS) among Jordanian patients: identifying the influence of Ramadan fasting. Ann Med Surg (Lond) 2020; 59: 171-175
  • 49 Al Suwaidi J, Bener A, Gehani AA. et al. Does the circadian pattern for acute cardiac events presentation vary with fasting?. J Postgrad Med 2006; 52 (01) 30-33 , discussion 33–34
  • 50 Al Suwaidi J, Bener A, Hajar HA, Numan MT. Does hospitalization for congestive heart failure occur more frequently in Ramadan: a population-based study (1991-2001). Int J Cardiol 2004; 96 (02) 217-221
  • 51 Salam AM, Sulaiman K, Alsheikh-Ali AA. et al. Acute heart failure presentations and outcomes during the fasting month of Ramadan: an observational report from seven Middle Eastern countries. Curr Med Res Opin 2018; 34 (02) 237-245
  • 52 Abazid RM, Khalaf HH, Sakr HI. et al. Effects of Ramadan fasting on the symptoms of chronic heart failure. Saudi Med J 2018; 39 (04) 395-400
  • 53 Abdolreza N, Omalbanin A, Mahdieh TS. et al. Comparison of the number of patients admitted with renal colic during various stages of peri-Ramadan month. Saudi J Kidney Dis Transpl 2011; 22 (06) 1199-1202
  • 54 al-Hadramy MS. Seasonal variations of urinary stone colic in Arabia. J Pak Med Assoc 1997; 47 (11) 281-284
  • 55 Sagy I, Zeldetz V, Halperin D, Abu Tailakh M, Novack V. The effect of Ramadan fast on the incidence of renal colic emergency department visits. QJM 2017; 110 (09) 571-576
  • 56 Hill FJ, Sayer JA. Re: Sagy I, Zeldetz V, Halerin D, Abu Tailakh M, Novack V. The effect of Ramadan fast on the incidence of renal colic emergency department visits. QJM 2018; 111 (05) 353-354
  • 57 Al Mahayni AO, Alkhateeb SS, Abusaq IH, Al Mufarrih AA, Jaafari MI, Bawazir AA. Does fasting in Ramadan increase the risk of developing urinary stones?. Saudi Med J 2018; 39 (05) 481-486
  • 58 Cevik Y, Corbacioglu SK, Cikrikci G, Oncul V, Emektar E. The effects of Ramadan fasting on the number of renal colic visits to the emergency department. Pak J Med Sci 2016; 32 (01) 18-21
  • 59 Al Wakeel JS. Kidney function and metabolic profile of chronic kidney disease and hemodialysis patients during Ramadan fasting. Iran J Kidney Dis 2014; 8 (04) 321-328
  • 60 AlAbdan NA, Almohammed OA, Altukhaim MS. et al. Fasting during Ramadan and acute kidney injury (AKI): a retrospective, propensity matched cohort study. BMC Nephrol 2022; 23 (01) 54
  • 61 Wan Md Adnan WA, Zaharan NL, Wong MH, Lim SK. The effects of intermittent fasting during the month of Ramadan in chronic haemodialysis patients in a tropical climate country. PLoS One 2014; 9 (12) e114262
  • 62 Adanan NIH, Adnan WAHWM, Khosla P, Karupaiah T, Daud ZAM. Exploring the experiences and perceptions of haemodialysis patients observing Ramadan fasting: a qualitative study. BMC Nephrol 2021; 22 (01) 48
  • 63 Al-Kaabi S, Bener A, Butt MT. et al. Effect of Ramadan fasting on peptic ulcer disease. Indian J Gastroenterol 2004; 23 (01) 35
  • 64 Kucuk HF, Censur Z, Kurt N. et al. The effect of Ramadan fasting on duodenal ulcer perforation: a retrospective analysis. Indian J Surg 2005; 67 (04) 195-198
  • 65 Bener A, Derbala MF, Al-Kaabi S. et al. Frequency of peptic ulcer disease during and after Ramadan in a United Arab Emirates hospital. East Mediterr Health J 2006; 12 (1-2): 105-111
  • 66 Emami MH, Rahimi H. Effects of Ramadan fasting on acute upper gastrointestinal bleeding due to peptic ulcer. J Res Med Sci 2006; 11 (03) 170-175
  • 67 Ozkan S, Durukan P, Akdur O, Vardar A, Torun E, Ikizceli I. Does Ramadan fasting increase acute upper gastrointestinal haemorrhage?. J Int Med Res 2009; 37 (06) 1988-1993
  • 68 Drozdinsky G, Agabaria A, Zuker-Herman R, J Drescher M, Bleetman T, Shiber S. High rate of acute pancreatitis during the Ramadan fast. Eur J Gastroenterol Hepatol 2018; 30 (06) 608-611
  • 69 Tabrizi N, Karimi N. Clinical epidemiologic study of admissions due to neurologic diseases during and after Ramadan fasting, Sari, Iran, 2015. J Mazandaran Univ Med Sci 2019; 29 (179) 117-125
  • 70 Drescher MJ, Wimpfheimer Z, Abu Khalef S, Gammaitoni A, Shehadeh N, Torgovicky R. Prophylactic etoricoxib is effective in preventing “first of Ramadan” headache: a placebo-controlled double-blind and randomized trial of prophylactic etoricoxib for ritual fasting headache. Headache 2012; 52 (04) 573-581
  • 71 Bener A, Hamad A, Fares A, Al-Sayed HM, Al-Suwaidi J. Is there any effect of Ramadan fasting on stroke incidence?. Singapore Med J 2006; 47 (05) 404-408
  • 72 Assy MH, Awd M, Elshabrawy AM, Gharieb M. Effect of Ramadan fasting on incidence of cerebrovascular stroke in Egyptian patients with type 2 diabetes mellitus. Diabetes Res Clin Pract 2019; 151: 299-304
  • 73 Saadatnia M, Zare M, Fatehi F, Ahmadi A. The effect of fasting on cerebral venous and dural sinus thrombosis. Neurol Res 2009; 31 (08) 794-798
  • 74 El-Mitwalli A, Zaher AA, Mohamed MAE, Elmenshawi E. The effect of Ramadan fasting on cerebral stroke: a prospective hospital-based study. Egypt J Neurol Psychiat Neurosurg 2009; 46 (01) 51-56
  • 75 Salama HH, Belal T. Is there any consequence of Ramadan fasting on acute cerebral stroke?. Egypt J Neurol Psychiat Neurosurg 2014; 51 (03) 333-336
  • 76 Magdy R, Kishk NA, Abokrysha NT, Ramzy GM, Rizk HI, Hussein M. Fasting and post fasting effect of Ramadan on different seizure types in patients with active epilepsy. Nutr Neurosci 2022; 25 (05) 1100-1104
  • 77 Mzoughi K, Zairi I, Fennira S. et al. Effect of Ramadan fasting on acenocoumarol-induced anticoagulant effect. Ann Biol Clin (Paris) 2017; 75 (05) 513-518
  • 78 Lai YF, Cheen MH, Lim SH. et al. The effects of fasting in Muslim patients taking warfarin. J Thromb Haemost 2014; 12 (03) 349-354
  • 79 Alwhaibi A, Alenazi M, Alwagh F. et al. Does Ramadan fasting disrupt international normalised ratio control in warfarin-treated medically stable patients?. Int J Clin Pract 2021; 75 (11) e14796
  • 80 Leo A, La Tegola D, Logroscino G, Carabellese F. Approach to the patient hospitalized during the Muslim Ramadan: bioethical and clinical considerations. Riv Psichiatr 2016; 51 (05) 172-176
  • 81 Erbay H, Alan S, Kadıoğlu S. A case study from the perspective of medical ethics: refusal of treatment in an ambulance. J Med Ethics 2010; 36 (11) 652-655