CC BY 4.0 · Journal of Health and Allied Sciences NU
DOI: 10.1055/s-0043-1764359
Original Article

Factors Associated with Recurrence in Chronic Subdural Hematoma following Surgery

1   Division of Neurosurgery, Department of Surgery, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand
2   Division of Neurosurgery, Department of Surgery, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand
› Author Affiliations
Funding None.


Background Recurrence is a frequent complication after surgery in a chronic subdural hematoma (CSDH). This study aimed to describe the recurrent rate of CSDH after surgery. In addition, a secondary objective aimed to explore factors associated with the recurrence of CSDH after surgery.

Methods A total of 141 surgical CSDH patients were analyzed in this retrospective study. The Cox regression method was used to conduct both univariate and multivariate analyses of variables associated with recurrence. As a result, the cumulative incidence of recurrence for each covariate survival curve was built after the final model.

Results Twenty-two percent of the patients showed evidence of recurrence. Initially, four variables (Glasgow coma scale score 3–8, clopidogrel, operative time, and amount of irrigated saline) had potential factors in univariate analysis but only clopidogrel and amount of saline irrigation were significantly associated with CSDH recurrence.

Conclusion Preoperative clopidogrel and the amount of saline irrigation were found to be associated with the recurrence rate. Factors associated with CSDH recurrence should be developed and validated as the clinical prediction tool for implication in general practice.

Ethical Approval

A human research ethics committee of Faculty of Medicine, Prince of Songkla University approved this study (REC 64–395–10–1) on September, 14 2021.

Authors' Contributions

KB and TT conceived the study and designed the method. KB supervised the completion of the data collection. TT undertook the recruitment of participating centers and patients and managed the data, including quality control. TT provided statistical advice on the study design and analyzed the data, while KB drafted the manuscript, and all authors contributed substantially to its revision. TT and KB take responsibility for the paper as a whole.

Publication History

Article published online:
18 April 2023

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