Development of a cochlear implantation-related mechanical injury model in miniature pigs

Introduction To avoid mechanical injuries related to the process of cochlear implantation, the physical properties of the cochlea and cochlear electrodes should be studied. To further explore and determine possible mechanical injury during cochlear implantation, we developed a cochlear implantation-related mechanical injury model in miniature pigs. 2.

Materials and methods 2.1. Cochlea model of Bama miniature pigs and parameter measurements (1) finite element model of Bama miniature pigs cochlea:10 Bama miniature pigs were dissected to obtain the intact cochlea. (2) Study of basilar membrane rupture force in miniature pigs:10 fresh(postmortem<24h), nonfixed, never-frozen cochlea of miniature pigs were prepared to obtain the cochlear basilar membrane, including surgical separation of the cochlea by removing the bone covering the scala tympani (ST) and the scala vestibuli (SV) to expose the basilar membrane(FIG.2.) 2.2. Cochlear electrode models and parameter measurements. Based on the micro-lateral force stretching technique, the electrodes were stretched in parallel by a transducer fixed to a cantilever beam. 2.3. Finite element interaction model A 3D model of the cochlear bone wall and the basilar membrane was reconstructed using the images, and a 3D model of the cochlear electrode was created, with boundary conditions set separately. Results 3.1. Miniature pig cochlear model and parameter measurements 3.2. Cochlear electrode models and parameter measurements 3.3. Finite element interaction modeling 4.

Conclusion  The mechanical parameters of the miniature pig cochlear basilar membrane and cochlear electrode were obtained through this experiment, and it was proved that it is relatively feasible to establish a cochlear implantation-related mechanical injury model.

Publication History

Article published online:
12 May 2023