Laryngorhinootologie 2023; 102(S 02): S278
DOI: 10.1055/s-0043-1767381
Abstracts | DGHNOKHC
Otology/Neurootology/Audiology:Cochlear implant

Volumetric analysis of grey and white matter in children and parents with single-sided deafness – a retrospective MRI study II

Ann-Kathrin Rauch
1   Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg, Germany, Department of Otorhinolaryngology – Head and Neck Surgery
,
Alexander Rau
2   Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg, Germany, Department of Neuroradiology
,
Marco Reisert
3   Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg, Germany, Department of Medical Physics
,
Philipp Arnold
2   Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg, Germany, Department of Neuroradiology
,
Horst Urbach
2   Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg, Germany, Department of Neuroradiology
,
Thomas Neuhaus
1   Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg, Germany, Department of Otorhinolaryngology – Head and Neck Surgery
,
Susan Arndt
1   Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg, Germany, Department of Otorhinolaryngology – Head and Neck Surgery
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Purpose Recently, cochlear implant (CI) was established as a treatment for single-sided deafness (SSD) in adults and children. We investigated the volume of the primary auditory cortex and regions with known cross-modal plasticity (visual cortex, somatosensory cortex) in SSD to assess potential biomarkers for the outcome and success of CI surgery.

Methods Retrospectively, we compared MRI data (total n=162) of children and adults with SSD with an age- and gender-matched group of bilaterally deaf patients. For the adult group, in addition, we compared the results with patients who had a short history of deafness (i.e., sudden hearing loss). Grey matter (GM) and white matter (WM) tissue probabilty values as derived by CAT 12 were read out using a probablistic atlas approach for the primary auditory cortex, and visual and somatosensory cortex. Regional GM and WM values were compared between patients with SSD and bilateral deafness patients, taking the side of deafness in SSD into account.

Results Our preliminary results showed different volumetric left-right side differences of the auditory pathway for children and adults with SSD compared to an age- and gender-matched bilaterally deaf group and SSD group with short history of deafness (adults). Left-right asymmetry was present depending on side of SSD; results were e.g. for Heschl Gyrus not significant (p>0.05). For WM, differences between SSD and bilateral deafness were correlated.

Conclusion Our preliminary data point to that there is a regionally-specific volume adaptation of GM in SSD vs. bilaterally deaf patients, which presents differently in pediatric and adult patients. Regarding WM, a correlated volume adaptation was shown. Prospective data are needed to draw conclusions about outcome.



Publication History

Article published online:
12 May 2023

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