CC BY-NC-ND 4.0 · J Lab Physicians 2023; 15(04): 608-612
DOI: 10.1055/s-0043-1768632
Case Report

Synchronous Malignancies: Pathological Analysis of Three Patients, Each with Dual Malignancies

1   Department of Pathology, Lady Hardinge Medical College, New Delhi, India
,
1   Department of Pathology, Lady Hardinge Medical College, New Delhi, India
,
1   Department of Pathology, Lady Hardinge Medical College, New Delhi, India
,
Gunjan Saini
1   Department of Pathology, Lady Hardinge Medical College, New Delhi, India
,
Romesh Lal
2   Department of Surgery, Lady Hardinge Medical College, New Delhi, India
,
Ratna Biswas
3   Department of Obstetrics and Gynecology, Lady Hardinge Medical College, New Delhi, India
› Author Affiliations
Funding The authors received no financial support for the research, authorship, and/or publication of this article.

Abstract

Multiple primary malignancies are defined as two or more malignancies arising independently to each other in the same or different anatomical sites, while excluding the possibility of metastasis from the primary malignancy. Here, we present three cases, each with dual malignancies involving different anatomical locations.

Guarantor of Submission

The corresponding author is the guarantor of submission.


Declaration of Patient Consent

The authors certify that they have obtained the appropriate consent from the patient's parents. The parents have given their consent for the images and other clinical information to be reported in the journal. The parents understand that the name and initials will not be published.




Publication History

Received: 27 December 2022

Accepted: 14 March 2023

Article published online:
19 May 2023

© 2023. The Indian Association of Laboratory Physicians. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India

 
  • References

  • 1 Maxwell KN, Wenz BM, Kulkarni A. et al. Mutation rates in cancer susceptibility genes in patients with breast cancer with multiple primary cancers. JCO Precis Oncol 2020; 4: PO.19.00301
  • 2 Coyte A, Morrison DS, McLoone P. Second primary cancer risk - the impact of applying different definitions of multiple primaries: results from a retrospective population-based cancer registry study. BMC Cancer 2014; 14: 272
  • 3 Warren S, Gates O. Multiple primary malignant tumors, a survey of the literature and statistical study. Am J Cancer 1932; 16: 1358-1414
  • 4 Zhai C, Cai Y, Lou F. et al. Multiple primary malignant tumors - a clinical analysis of 15,321 patients with malignancies at a single center in China. J Cancer 2018; 9 (16) 2795-2801
  • 5 Pan SY, Huang CP, Chen WC. Synchronous/metachronous multiple primary malignancies: review of associated risk factors. Diagnostics (Basel) 2022; 12 (08) 1940
  • 6 Lu HM, Li S, Black MH. et al. Association of breast and ovarian cancers with predisposition genes identified by large-scale sequencing. JAMA Oncol 2019; 5 (01) 51-57 [published correction appears in JAMA Oncol. 2019 Jan 1;5(1):122]
  • 7 Zhang J, Gao J, Cui J. et al. Tumor-associated macrophages in tumor progression and the role of traditional Chinese medicine in regulating TAMs to enhance antitumor effects. Front Immunol 2022; 13: 1026898
  • 8 Calderwood AH, Huo D, Rubin DT. Association between colorectal cancer and urologic cancers. Arch Intern Med 2008; 168 (09) 1003-1009
  • 9 Lacouture ME, O'Reilly K, Rosen N, Solit DB. Induction of cutaneous squamous cell carcinomas by RAF inhibitors: cause for concern?. J Clin Oncol 2012; 30 (03) 329-330