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CC BY 4.0 · Arq Neuropsiquiatr 2023; 81(06): 597-606
DOI: 10.1055/s-0043-1768676
Brazilian Academy of Neurology

Ketogenic therapy in childhood and adolescence: recommendations of the Brazilian experts group

Terapia cetogênica na infância e adolescência: recomendações do grupo de especialistas brasileiros
Letícia Pereira de Brito Sampaio 
1   Universidade de São Paulo, Faculdade de Medicina, Hospital das Clínicas, Instituto da Criança e Adolescente, São Paulo SP, Brazil.
,
Adélia Maria de Miranda Henriques-Souza 
2   Instituto de Medicina Integral Professor Fernando Figueira, Centro de Terapias Cetogênicas do IMIP, Recife PE, Brazil.
,
Katia Lin 
3   Universidade Federal de Santa Catarina, Departamento de Medicina Interna, Divisão de Neurologia, Florianópolis SC, Brazil.
,
Lenycia de Cassya Lopes Neri 
1   Universidade de São Paulo, Faculdade de Medicina, Hospital das Clínicas, Instituto da Criança e Adolescente, São Paulo SP, Brazil.
,
Luciana Midori Inuzuka 
4   Hospital Sirio Libanês, Departamento de Neurofisiologia, São Paulo SP, Brazil.
,
Ludmila Inácio de Lima Uchôa 
5   Hospital Materno-Infantil de Brasília, Brasília DF, Brazil.
,
Marcela Marques de Oliveira Gregório 
6   Universidade Federal de São Paulo, Departamento de Neurologia, São Paulo, Brazil.
,
Laura Maria Guilhoto 
6   Universidade Federal de São Paulo, Departamento de Neurologia, São Paulo, Brazil.
12   Universidade de São Paulo, Hospital Universitário, Divisão de Clínica Pediátrica, São Paulo SP, Brazil.
,
Maria Augusta Montenegro 
7   Universidade Estadual de Campinas, Departamento de Neurologia, São Paulo SP, Brazil.
,
Mariana Lunardi 
8   Universidade Federal de Santa Catarina, Programa de Pós-Graduação em Ciências Médicas, Florianópolis SC, Brazil.
,
Marielza Veiga 
9   Hospital Universitário Professor Edgard Santos, Salvador BA, Brazil.
,
Patricia Azevedo de Lima 
10   Universidade Anhanguera, São Paulo SP, Brazil.
,
Vera Braatz 
11   Universidade da Região de Joinville, Departamento de Medicina, Divisão de Neurologia, Joinville SC, Brazil.
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Abstract

Ketogenic dietary therapies (KDTs) are a safe and effective treatment for pharmacoresistant epilepsy in children. There are four principal types of KDTs: the classic KD, the modified Atkins diet (MAD), the medium-chain triglyceride (MCT) diet, and the low glycemic index diet (LGID). The International Ketogenic Diet Study Group recommends managing KDTs in children with epilepsy. However, there are no guidelines that address the specific needs of the Brazilian population. Thus, the Brazilian Child Neurology Association elaborated on these recommendations with the goal of stimulating and expanding the use of the KD in Brazil.

Resumo

As terapias dietéticas cetogênicas (TDC) são um tratamento seguro e eficaz para epilepsia farmacorresistente em crianças. Existem quatro tipos principais de TDCs: a dieta cetogênica (DC) clássica, a dieta de Atkins modificada (DAM), a dieta de triglicerídeos de cadeia média (DTCM) e a dieta de baixo índice glicêmico (DBIG). O Grupo Internacional de Estudos de Dietas Cetogênicas (International Ketogenic Diet Study Group) propõe recomendações para o manejo da DC em crianças com epilepsia. No entanto, faltam diretrizes que contemplem as necessidades específicas da população brasileira. Assim, a Associação Brasileira de Neurologia Infantil elaborou essas recomendações com o objetivo de estimular e expandir o uso da DC no Brasil.

Keywords

Diet, Ketogenic - Drug Resistant Epilepsy - Neurology - Brain Diseases

Palavras-chave

Dieta Cetogênica - Epilepsia Resistente a Medicamentos - Neurologia - Encefalopatias

Authors' Contributions

All authors equally contributed through online discussions and by reviewing all draft versions of the text and tables. All authors approved the submitted version of the manuscript.


Support

KL holds a CNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico) PQ2 Research Fellowship (Process No. 313205/2020-5) and is supported by PRONEM – KETODIET-SC-Project – FAPESC/CNPq, Brazil – Process No. 2020TR736.




Publication History

Received: 17 November 2022

Accepted: 15 February 2023

Article published online:
28 June 2023

© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution 4.0 International License, permitting copying and reproduction so long as the original work is given appropriate credit (https://creativecommons.org/licenses/by/4.0/)

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