Bariatric surgery (RyGB) reduces tumor invasiveness and growth in colorectal carcinoma in a RYGB-CRC mouse model

Introduction Colorectal carcinoma (CRC) is one of the leading cause of death while obesity is described as a major risk factor. Clinically, the positive effects after metabolic-bariatric surgery on cancer risk on different cancer entities are described, especially in CRC.

Methods To investigate these impressive results, we developed a metabolic-bariatric mouse model in form of a classic Roux-Y-gastric bypass (RyGB) and implanted in a second step CRC-organoids under the subserosa of the cecum of the mice.

Results Mice with a RyGB developed significantly lower tumor volume than the control groups and showed additionally no hepatic metastasis, while the control groups developed multiple liver metastases. Analysis of the CRC tumormicroenvironment showed that RyGB operation leads to significant antitumoral immunological changes.

Conclusion RYGB operation leads to a protective effect regarding carcinogenesis and invasiveness of CRC.

Publikationsverlauf

Artikel online veröffentlicht:
28. August 2023