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CC BY 4.0 · Indian J Med Paediatr Oncol 2024; 45(04): 346-350
DOI: 10.1055/s-0043-1772233
Case Report with Review of Literature

Double-Expressor Lymphoma in a Young Child—A Case Report and Review of Literature

Anjali Shaju
1   Department of Pediatrics, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai, Tamil Nadu, India
,
Latha M. Sneha
2   Department of Pediatric Hematology and Oncology, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai, Tamil Nadu, India
,
Nidarshana Pandian
1   Department of Pediatrics, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai, Tamil Nadu, India
,
Suresh Chandra
3   Histopathology, Medgenome, Bangalore, Karnataka, India
,
Sonam Poonam Nisar
4   Department of Orbit, Oculoplasty, Reconstructive and Aesthetic Services, Sankara Nethralaya, Chennai, Tamil Nadu, India
,
Krishnakumar Subramanian
5   Pathology Department, Vision Research Foundation, Chennai, Tamil Nadu, India
,
Priyathersini Nagarajan 
6   Department of Pathology, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai, Tamil Nadu, India
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Funding The authors received no financial support for the research, authorship, and/or publication of this article.
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Abstract

Double hit lymphoma (DHL) and double-expressor lymphoma (DEL) are now considered as aggressive types of diffuse large B cell lymphoma. DHL is characterized by a dual rearrangement of MYC and B cell lymphoma 2 (BCL-2) and/or B cell lymphoma 6 (BCL-6) and DEL by overexpression of MYC and BCL-2. Both DHL and DEL have aggressive presentation and are more common in elderly population. We present a case of 1 ½ years old boy who presented with bilateral proptosis, and diagnosed as non-Hodgkin lymphoma with central nervous system involvement. Immunohistochemistry revealed high expression of MYC and BCL-2. Fluorescence in situ hybridization studies done to rule out DHL showed no translocation of C-MYC, Bcl-2, and Bcl-6 and hence were confirmed as double-expressor high-grade B cell lymphoma. Dual expression of C- MYC, Bcl-2, or Bcl-6 always needs further evaluation to rule out the more aggressive DHL subtypes.

Keywords

child - proptosis - non-Hodgkin lymphoma - double-expressor lymphoma

Authors’ Contributions

Latha MS conceptualized the report, performed literature review, and edited the manuscript. Anjali Shaju and Nidarshana Pandian drafted the manuscript. Krishnakumar, Suresh Chandra, Priyathersini, and Sonam Poonam edited and revised the manuscript. All authors read and approved the manuscript for publication.


Patient's Consent

Informed consent was obtained from all individual participants included in the study.




Publication History

Article published online:
22 September 2023

© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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