CC BY 4.0 · Avicenna J Med 2023; 13(04): 247-252
DOI: 10.1055/s-0043-1775997
Case Report

Primary Sarcomas of the Larynx: A Case Series of Four Different Histopathologic Types

1   Division of Anatomic Pathology, Hamad Medical Corporation, Doha 576214, Qatar
Khaled A. Murshed
1   Division of Anatomic Pathology, Hamad Medical Corporation, Doha 576214, Qatar
Adham Ammar
1   Division of Anatomic Pathology, Hamad Medical Corporation, Doha 576214, Qatar
1   Division of Anatomic Pathology, Hamad Medical Corporation, Doha 576214, Qatar
› Author Affiliations
Funding No funding was received.


Primary laryngeal sarcomas are rare. Their nomenclature and classification are similar to soft tissue counterparts; however, there are notable differences between clinical presentation, behavior, treatment, and follow-up. There is sparse information regarding the clinical features, biologic behavior, and treatment modalities of laryngeal sarcomas. To increase our understanding about these tumors, we describe herein an additional series of four cases of different pathologic types of laryngeal sarcomas, including low-grade chondrosarcoma, leiomyosarcoma, well-differentiated liposarcoma, and undifferentiated pleomorphic sarcoma. Our main aim is to upsurge awareness about the morphologic variations of laryngeal sarcomas, to avoid potential pitfalls during histopathologic examination. It is essential to ensure that correct diagnosis, subclassification, and grading are achieved for proper guidance of treatment and clinical follow-up at multidisciplinary team meetings.

Consent to Publish

Informed consent from the participant has been waived by Institutional Review Board.

Ethical Approval

The Institutional Review Board at Hamad Medical Corporation approved publication of this article under the number (MRC-04–21–908).

Data Availability Statement

The data that support the findings of this study are available from the corresponding author upon reasonable request.

*These authors contributed equally.

Publication History

Article published online:
11 December 2023

© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (

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  • References

  • 1 Velez Torres JM, Martinez Duarte E, Diaz-Perez JA. et al. Primary sarcomas of the larynx: a clinicopathologic study of 27 cases. Head Neck Pathol 2021; 15 (03) 905-916
  • 2 Ramdulari AV, Izzuddeen Y, Benson R, Mallick S, Venkatesulu B, Giridhar P. Laryngeal soft tissue sarcoma: systematic review and individual patient data analysis of 300 cases. Head Neck 2021; 43 (05) 1421-1427
  • 3 Astl J, Holy R, Tuckova I, Belsan T, Pala M, Rotnagl J. Sarcomas of the larynx: one institution's experience and treatment protocol analyses. Medicina (Kaunas) 2021; 57 (03) 192
  • 4 AbdullGaffar B, Keloth T. Laryngeal sarcomas: a case series of 5 cases. Ann Diagn Pathol 2018; 37: 35-41
  • 5 Bayır Ö, Karagöz T, Han Ü. et al. A report of 4 laryngeal sarcoma patients. JSM Clin Case Rep. 2016; 4 (03) 1105-1109
  • 6 Thompson LD, Gannon FH. Chondrosarcoma of the larynx: a clinicopathologic study of 111 cases with a review of the literature. Am J Surg Pathol 2002; 26 (07) 836-851
  • 7 Coca-Pelaz A, Rodrigo JP, Triantafyllou A. et al. Chondrosarcomas of the head and neck. Eur Arch Otorhinolaryngol 2014; 271 (10) 2601-2609
  • 8 Talati VM, Urban MJ, Patel TR. et al. Laryngeal chondrosarcoma characteristics and survival analysis in the National Cancer Database. Otolaryngol Head Neck Surg 2022; 166 (01) 101-108
  • 9 Marioni G, Bertino G, Mariuzzi L, Bergamin-Bracale AM, Lombardo M, Beltrami CA. Laryngeal leiomyosarcoma. J Laryngol Otol 2000; 114 (05) 398-401
  • 10 Marioni G, Staffieri C, Marino F, Staffieri A. Leiomyosarcoma of the larynx: critical analysis of the diagnostic role played by immunohistochemistry. Am J Otolaryngol 2005; 26 (03) 201-206
  • 11 Sauter A, Bersch C, Lambert KL, Hörmann K, Naim R. Chondrosarcoma of the larynx and review of the literature. Anticancer Res 2007; 27 (4C): 2925-2929
  • 12 Wenig BM, Weiss SW, Gnepp DR. Laryngeal and hypopharyngeal liposarcoma. A clinicopathologic study of 10 cases with a comparison to soft-tissue counterparts. Am J Surg Pathol 1990; 14 (02) 134-141
  • 13 Binh MB, Sastre-Garau X, Guillou L. et al. MDM2 and CDK4 immunostainings are useful adjuncts in diagnosing well-differentiated and dedifferentiated liposarcoma subtypes: a comparative analysis of 559 soft tissue neoplasms with genetic data. Am J Surg Pathol 2005; 29 (10) 1340-1347
  • 14 Murshed KA, Abo Samra H, Ammar A. Well-differentiated liposarcoma of the hypopharynx exhibiting myxoid liposarcoma-like morphology with MDM2 and DDIT3 co-amplification. [published online ahead of print, 2021 Jun 4] Head Neck Pathol 2022; 16 (01) 288-293
  • 15 Jeong CY, Kim CS. Undifferentiated pleomorphic sarcoma of the vocal fold. Ear Nose Throat J 2016; 95 (12) E12-E14
  • 16 Haberal I, Samim E, Astarci M, Ozeri C. Radiation-induced malignant fibrous histiocytoma of the neck in a patient with laryngeal carcinoma. Am J Otolaryngol 2001; 22 (02) 146-149
  • 17 Cambruzzi E, Cruz R, Gava V, Pegas K. Undifferentiated high-grade pleomorphic sarcoma of the larynx treated with partial laringectomy. Rev Bras Otorrinolaringol (Engl Ed) 2020; 86 (Suppl 1, Suppl 1): 14-16
  • 18 Aljariri AA, Alsaleh AR, Al-Enazi HA. et al. Glottic malignant fibrous histiocytoma: a case report and literature review. Case Rep Oncol 2021; 14 (01) 641-646