Semin Musculoskelet Radiol 2024; 28(01): 014-025
DOI: 10.1055/s-0043-1776432
Review Article

Imaging Biomarkers of Osteoarthritis

1   Department of Radiology, Chobanian & Avedisian Boston University School of Medicine, Boston, Massachusetts
2   Department of Radiology, Universitätsklinikum Erlangen & Friedrich Alexander Universität (FAU) Erlangen–Nürnberg, Erlangen, Germany
3   Center of Anatomy, and Ludwig Boltzmann Institute for Arthritis and Rehabilitation (LBIAR), Paracelsus Medical University, Salzburg, Austria
4   Chondrometrics, GmbH, Freilassing, Germany
5   Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland
6   Department of Radiology, New York University Grossmann School of Medicine, New York, New York
Mohamed Jarraya
7   Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts
8   Department of Radiology, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts
9   Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts
3   Center of Anatomy, and Ludwig Boltzmann Institute for Arthritis and Rehabilitation (LBIAR), Paracelsus Medical University, Salzburg, Austria
4   Chondrometrics, GmbH, Freilassing, Germany
1   Department of Radiology, Chobanian & Avedisian Boston University School of Medicine, Boston, Massachusetts
10   Department of Radiology, Boston VA Healthcare System, West Roxbury, Massachusetts
› Author Affiliations


Currently no disease-modifying osteoarthritis drug has been approved for the treatment of osteoarthritis (OA) that can reverse, hold, or slow the progression of structural damage of OA-affected joints. The reasons for failure are manifold and include the heterogeneity of structural disease of the OA joint at trial inclusion, and the sensitivity of biomarkers used to measure a potential treatment effect.

This article discusses the role and potential of different imaging biomarkers in OA research. We review the current role of radiography, as well as advances in quantitative three-dimensional morphological cartilage assessment and semiquantitative whole-organ assessment of OA. Although magnetic resonance imaging has evolved as the leading imaging method in OA research, recent developments in computed tomography are also discussed briefly. Finally, we address the experience from the Foundation for the National Institutes of Health Biomarker Consortium biomarker qualification study and the future role of artificial intelligence.

Publication History

Article published online:
08 February 2024

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