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CC BY 4.0 · Arq Neuropsiquiatr 2023; 81(11): 961-969
DOI: 10.1055/s-0043-1777008
Original Article

Acousto-optic stimuli to promote coherent 40-Hz frequency entrainment effect

Estímulos acústico-ópticos para promover efeito de arrastamento de frequência coerente de 40 Hz
Xue Han 
1   Hebei University of Technology, School of Life Science and Health Engineering, Tianjin, China.
2   Hebei University of Technology, State Key Laboratory of Reliability and Intelligence of Electrical Equipment, Tianjin, China.
,
Lei Wang 
1   Hebei University of Technology, School of Life Science and Health Engineering, Tianjin, China.
2   Hebei University of Technology, State Key Laboratory of Reliability and Intelligence of Electrical Equipment, Tianjin, China.
,
Shuo Yang 
1   Hebei University of Technology, School of Life Science and Health Engineering, Tianjin, China.
2   Hebei University of Technology, State Key Laboratory of Reliability and Intelligence of Electrical Equipment, Tianjin, China.
› Institutsangaben Support The present work was supported in part by the National Natural Science Foundation of China, under grant 51877067.
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Abstract

Background Research has shown that a fundamental frequency of 40 Hz in continuous neural oscillation is indicative of normal brain activity; in Alzheimer disease (AD) patients, these oscillations either disappear or are significantly interrupted. Research has also indicated that the degenerative impacts of AD in mice were mitigated by the synchronization of 40-Hz acousto-optic stimulation (AOS).

Objective To examine the impact of employing a 40-Hz AOS intervention on the induction of a substantial 40-Hz frequency entrainment and improvement in working memory performance among a sample of young individuals in good health. We conduct an analysis of event-related potentials (ERPs) derived from electroencephalogram (EEG) data following the presentation of AOS.

Methods We recruited 20 healthy volunteers (median age: 25 years; 8 female subjects). Following the administration of various stimuli, including no stimuli, 40-Hz AOS, pink noise, and 40Hz acoustic stimuli (AS), the participants were required to complete a working memory task. A total of 62 electrodes were used to record EEG data, which was subsequently analyzed to investigate the impact of AOS on the activity of working memory. We also aimed to determine if AOS lead to a more pronounced 40-Hz frequency entrainment.

Results Following the administration of AOS, a notable enhancement in the 40-Hz power of pertinent cerebral areas was observed, accompanied by a substantial improvement in the performance of the subjects on working memory tests subsequent to the stimulation.

Conclusion The findings unequivocally establish the efficacy of using AOS to enhance the 40-Hz power and working memory.

Resumo

Antecedentes A pesquisa mostrou que uma frequência fundamental de 40 Hz em oscilação neural contínua é indicativa de atividade cerebral normal. Em pacientes com doença de Alzheimer (DA), essas oscilações desaparecem ou são significativamente interrompidas. A pesquisa também indicou que os impactos degenerativos da DA em camundongos foram mitigados pela sincronização da estimulação acústico-óptica (EAO) de 40 Hz.

Objetivo Examinar o impacto do emprego de uma intervenção EAO de 40 Hz na indução de um arrastamento substancial de frequência de 40 Hz e na melhoria do desempenho da memória de trabalho entre uma amostra de jovens com boa saúde. Conduzimos uma análise de potenciais relacionados a eventos (PREs) derivados de dados de eletroencefalograma (EEG) após a apresentação de EAO.

Métodos Recrutamos 20 voluntários saudáveis (idade média: 25 anos; 8 mulheres). Após a administração de vários estímulos, incluindo nenhum estímulo, EAO de 40 Hz, ruído rosa e estímulos acústicos (EA) de 40 Hz, os participantes foram obrigados a completar uma tarefa de memória de trabalho. Um total de 62 eletrodos foram utilizados para registrar dados de EEG, que foram posteriormente analisados. para investigar o impacto do AOS na atividade da memória de trabalho. Também pretendemos determinar se o AOS leva a um arrastamento de frequência de 40 Hz mais pronunciado.

Resultados Após a administração de AOS, foi observado um aumento notável na potência de 40 Hz de áreas cerebrais pertinentes, acompanhado por uma melhoria substancial no desempenho dos sujeitos em testes de memória de trabalho subsequentes à estimulação.

Conclusão Os resultados estabelecem inequivocamente a eficácia do uso do AOS para melhorar a potência de 40 Hz e a memória de trabalho.

Keywords

Alzheimer Disease - Electroencephalography - Memory, Short-Term

Palvras-chave

Doença de Alzheimer - Eletroencefalografia - Memória de Curto Prazo

Authors' Contributions

XH: conceptualization, data curation, formal analysis, investigation, and writing of the original draft; LW: supervision and writing – review and editing; SY: funding acquisition.




Publikationsverlauf

Eingereicht: 11. Dezember 2022

Angenommen: 26. August 2023

Artikel online veröffentlicht:
30. November 2023

© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution 4.0 International License, permitting copying and reproduction so long as the original work is given appropriate credit (https://creativecommons.org/licenses/by/4.0/)

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  • References

  • 1 Palop JJ, Mucke L. Network abnormalities and interneuron dysfunction in Alzheimer disease. Nat Rev Neurosci 2016; 17 (12) 777-792
    CrossrefPubMedGoogle Scholar
  • 2 Wang J, Fang Y, Wang X, Yang H, Yu X, Wang H. Enhanced Gamma Activity and Cross-Frequency Interaction of Resting-State Electroencephalographic Oscillations in Patients with Alzheimer's Disease. Front Aging Neurosci 2017; 9 (July): 243
    CrossrefPubMedGoogle Scholar
  • 3 Gillespie AK, Jones EA, Lin YH. et al. Apolipoprotein E4 Causes Age-Dependent Disruption of Slow Gamma Oscillations during Hippocampal Sharp-Wave Ripples. Neuron 2016; 90 (04) 740-751
    CrossrefPubMedGoogle Scholar
  • 4 Iaccarino HF, Singer AC, Martorell AJ. et al. Gamma frequency entrainment attenuates amyloid load and modifies microglia. Nature 2016; 540 (7632) 230-235
    CrossrefPubMedGoogle Scholar
  • 5 Dos Santos Picanco LC, Ozela PF, de Fatima de Brito Brito M. et al. Alzheimer's Disease: A Review from the Pathophysiology to Diagnosis, New Perspectives for Pharmacological Treatment. Curr Med Chem 2018; 25 (26) 3141-3159
    CrossrefPubMedGoogle Scholar
  • 6 Folch J, Ettcheto M, Petrov D. et al. Review of the advances in treatment for Alzheimer disease: Strategies for combating β-amyloid protein. Neurología (Engl Ed) 2018; 33 (01) 47-58 (English Edition)
    CrossrefPubMedGoogle Scholar
  • 7 Kastanenka KV, Hou SS, Shakerdge N. et al. Optogenetic Restoration of Disrupted Slow Oscillations Halts Amyloid Deposition and Restores Calcium Homeostasis in an Animal Model of Alzheimer's Disease. PLoS One 2017; 12 (01) e0170275
    CrossrefPubMedGoogle Scholar
  • 8 Martinez-Losa M, Tracy TE, Ma K. et al. Nav1.1-Overexpressing Interneuron Transplants Restore Brain Rhythms and Cognition in a Mouse Model of Alzheimer's Disease. Neuron 2018; 98 (01) 75-89.e5
    CrossrefPubMedGoogle Scholar
  • 9 da Silva VF, Ribeiro AP, Dos Santos VA, Nardi AE, King AL, Calomeni MR. Stimulation by Light and Sound: Therapeutics Effects in Humans. Systematic Review. Clin Pract Epidemiol Ment Health 2015; 11 (01) 150-154
    CrossrefPubMedGoogle Scholar
  • 10 Herrmann CS, Rach S, Neuling T, Strüber D. Transcranial alternating current stimulation: a review of the underlying mechanisms and modulation of cognitive processes. Front Hum Neurosci 2013; 7: 279-279
    CrossrefPubMedGoogle Scholar
  • 11 Calderone DJ, Lakatos P, Butler PD, Castellanos FX. Entrainment of neural oscillations as a modifiable substrate of attention. Trends Cogn Sci 2014; 18 (06) 300-309
    CrossrefPubMedGoogle Scholar
  • 12 Herrmann CS, Demiralp T. Human EEG gamma oscillations in neuropsychiatric disorders. Clin Neurophysiol 2005; 116 (12) 2719-2733
    CrossrefPubMedGoogle Scholar
  • 13 Belluscio MA, Mizuseki K, Schmidt R, Kempter R, Buzsáki G. Cross-frequency phase-phase coupling between θ and γ oscillations in the hippocampus. J Neurosci 2012; 32 (02) 423-435
    CrossrefPubMedGoogle Scholar
  • 14 McDermott B, Porter E, Hughes D. et al. Gamma Band Neural Stimulation in Humans and the Promise of a New Modality to Prevent and Treat Alzheimer's Disease. J Alzheimers Dis 2018; 65 (02) 363-392
    CrossrefPubMedGoogle Scholar
  • 15 Chan D, Suk HJ, Jackson BL. et al. Gamma Frequency Sensory Stimulation in Probable Mild Alzheimer's Dementia Patients: Results of a Preliminary Clinical Trial[J]. Social Science Electronic Publishing; 2021
    Google Scholar
  • 16 Adaikkan C, Tsai LH. Gamma Entrainment: Impact on Neurocircuits, Glia, and Therapeutic Opportunities. Trends Neurosci 2020; 43 (01) 24-41
    CrossrefPubMedGoogle Scholar
  • 17 He Q, Colon-Motas KM, Pybus AF. et al. A feasibility trial of gamma sensory flicker for patients with prodromal Alzheimer's disease. Alzheimers Dement (N Y) 2021; 7 (01) e12178
    CrossrefPubMedGoogle Scholar
  • 18 Mably AJ, Colgin LL. Gamma oscillations in cognitive disorders. Curr Opin Neurobiol 2018; 52: 182-187
    CrossrefPubMedGoogle Scholar
  • 19 Dvorak D, Radwan B, Sparks FT, Talbot ZN, Fenton AA. Control of recollection by slow gamma dominating mid-frequency gamma in hippocampus CA1. PLoS Biol 2018; 16 (01) e2003354
    CrossrefPubMedGoogle Scholar
  • 20 Jones M, McDermott B, Oliveira BL. et al. Gamma Band Light Stimulation in Human Case Studies: Groundwork for Potential Alzheimer's Disease Treatment. J Alzheimers Dis 2019; 70 (01) 171-185
    CrossrefPubMedGoogle Scholar
  • 21 Suk HJ, Chan D, Jackson B. et al. Sensory gamma frequency stimulation in cognitively healthy and AD individuals safely induces highly coordinated 40  Hz neural oscillation: A preliminary study of non-invasive sensory stimulation for treating Alzheimer's disease. Alzheimers Dement 2020; 16 (S7): e041146
    CrossrefGoogle Scholar
  • 22 Fatemi SN, Sedghizadeh MJ, Aghajan H. Theta-gamma phase-amplitude coupling explains the advantage of auditory plus visual gamma entrainment in Alzheimer's therapy. Alzheimers Dement 2022; 17 (S7): e053451
    CrossrefGoogle Scholar
  • 23 Bozhilova N, Kuntsi J, Rubia K, Michelini G, Asherson P. Electrophysiological modulation of sensory and attentional processes during mind wandering in attention-deficit/hyperactivity disorder. Neuroimage Clin 2021; 29 (04) 102547
    CrossrefPubMedGoogle Scholar
  • 24 Arjona-Valladares A, Fondevila-Estévez S, Fernández-Linsenbarth I. et al. Event-related potentials associated to N-back test performance in schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry 2021; 111: 110347
    CrossrefPubMedGoogle Scholar
  • 25 Turtola ZP, Covey TJ. Working memory training impacts neural activity during untrained cognitive tasks in people with multiple sclerosis. Exp Neurol 2021; 335: 113487
    CrossrefPubMedGoogle Scholar
  • 26 Sun T, Li L, Xu Y. et al. Electrophysiological evidence for women superiority on unfamiliar face processing. Neurosci Res 2017; 115: 44-53
    CrossrefPubMedGoogle Scholar
  • 27 Polich J. Updating P300: an integrative theory of P3a and P3b. Clin Neurophysiol 2007; 118 (10) 2128-2148
    CrossrefPubMedGoogle Scholar
  • 28 Ortega R, López V, Carrasco X. et al. Neurocognitive mechanisms underlying working memory encoding and retrieval in Attention-Deficit/Hyperactivity Disorder. Sci Rep 2020; 10 (01) 7771
    CrossrefPubMedGoogle Scholar
  • 29 Sahin L, Figueiro MG. Flickering red-light stimulus for promoting coherent 40hz neural oscillation: a feasibility study. J Alzheimers Dis 2020; 75 (03) 911-921
    CrossrefPubMedGoogle Scholar
  • 30 Callahan-Flintoft C, Wyble B. Non-singleton colors are not attended faster than categories, but they are encoded faster: A combined approach of behavior, modeling and ERPs. Vision Res 2017; 140: 106-119
    CrossrefPubMedGoogle Scholar
  • 31 Schubert AL, Hagemann D, Frischkorn GT, Herpertz SC. Faster, but not smarter: An experimental analysis of the relationship between mental speed and mental abilities. Intelligence 2018; 71: 66-75
    CrossrefGoogle Scholar
  • 32 Donchin E, Coles MGH. Is the P300 component a manifestation of context updating?. Behav Brain Sci 1988; 11 (03) 357-374
    CrossrefGoogle Scholar
  • 33 Zacks J, Rypma B, Gabrieli JD, Tversky B, Glover GH. Imagined transformations of bodies: an fMRI investigation. Neuropsychologia 1999; 37 (09) 1029-1040
    CrossrefPubMedGoogle Scholar
  • 34 Jonides J, Lacey SC, Nee DE. Processes of working memory in mind and brain. Curr Dir Psychol Sci 2005; 14 (01) 2-5
    CrossrefGoogle Scholar