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CC BY 4.0 · World J Nucl Med 2023; 22(04): 261-266
DOI: 10.1055/s-0043-1777693
Original Article

Predictors of Bilateral SLN Radiocolloid Detection in Endometrial Carcinoma

Anamarija Jankulovska
1   Institute of Pathophysiology and Nuclear Medicine “Acad Isac S. Tadzer”, Faculty of Medicine, University of “Ss. Cyril and Methodius”, Skopje, Republic of North Macedonia
,
Sasho Stojcevski
2   University Clinic for Obstetrics and Gynecology, Skopje, Republic of North Macedonia
,
Igor Aluloski
2   University Clinic for Obstetrics and Gynecology, Skopje, Republic of North Macedonia
,
Mile Tanturovski
2   University Clinic for Obstetrics and Gynecology, Skopje, Republic of North Macedonia
,
Nevena Manevska
1   Institute of Pathophysiology and Nuclear Medicine “Acad Isac S. Tadzer”, Faculty of Medicine, University of “Ss. Cyril and Methodius”, Skopje, Republic of North Macedonia
,
Ana Daneva Markova
2   University Clinic for Obstetrics and Gynecology, Skopje, Republic of North Macedonia
,
Sinisa Stojanoski
1   Institute of Pathophysiology and Nuclear Medicine “Acad Isac S. Tadzer”, Faculty of Medicine, University of “Ss. Cyril and Methodius”, Skopje, Republic of North Macedonia
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Abstract

Introduction Sentinel lymph node (SLN) mapping is an alternative method to conventional lymphadenectomy for nodal status assessment in patients with stage I/II endometrial carcinoma (EC). This study aimed to analyze the potential predictors of unsuccessful bilateral detection of SLN after the application of radiocolloid in EC.

Materials and Methods A prospective, observational, cross-sectional study was performed on 41 patients with EC in preoperative stage I, who underwent SLN mapping after cervical application of 4mCi 99mTc-SENTI-SCINT. The demographic, clinical, and tumor-related data were obtained from the patient's medical records. Univariate analysis was used to analyze the potential factors associated with an unsuccessful bilateral SLN biopsy.

Results The bilateral SLN detection rate of planar lymphoscintigraphy, single photon emission computed tomography/computed tomography, and gamma probe was 29.26, 41.46, and 26.82%, correspondingly. None of the 16 analyzed risk factors showed statistical significance for nonconclusive bilateral SLN biopsy.

Conclusion Larger scale studies are needed to determine the exact risk factors for unsuccessful bilateral mapping of the lymphatic drainage after cervical application of the radiotracers. This will eventually lead to improvement in bilateral SLN detection in EC patients, so unilateral lymphadenectomy could be avoided.

Keywords

endometrial carcinoma - sentinel lymph node biopsy - risk factors - radiocolloid - bilateral lymphatic drainage


Publication History

Article published online:
26 December 2023

© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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