Update Breast Cancer 2018 (Part 1) – Primary Breast Cancer and Biomarkers

Florin-Andrei Taran; Andreas Schneeweiss; Michael P. Lux; Wolfgang Janni; Andreas D. Hartkopf; Naiba Nabieva; Friedrich Overkamp; Hans-Christian Kolberg; Peyman Hadji; Hans Tesch; Achim Wöckel; Johannes Ettl; Diana Lüftner; Markus Wallwiener; Volkmar Müller; Matthias W. Beckmann; Erik Belleville; Diethelm Wallwiener; Sara Y. Brucker; Peter A. Fasching; Tanja N. Fehm; Florian Schütz

doi:10.1055/s-0044-101613

Geburtshilfe und Frauenheilkunde, Table of Contents

CC BY-NC-ND 4.0 · Geburtshilfe Frauenheilkd 2018; 78(03): 237-245
DOI: 10.1055/s-0044-101613

GebFra Science

Review/Übersicht

Georg Thieme Verlag KG Stuttgart · New York

Update Mammakarzinom 2018 (Teil 1) – primäres Mammakarzinom und Biomarker

Article in several languages: English | deutsch

Authors

Florin-Andrei Taran

¹Department of Obstetrics and Gynecology, University of Tübingen, Tübingen, Germany
Andreas Schneeweiss

²National Center for Tumor Diseases, Division Gynecologic Oncology, University Hospital Heidelberg, Heidelberg, Germany

³Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany
Michael P. Lux

⁴Erlangen University Hospital, Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany
Wolfgang Janni

⁵Department of Gynecology and Obstetrics, Ulm University Hospital, Ulm, Germany
Andreas D. Hartkopf

¹Department of Obstetrics and Gynecology, University of Tübingen, Tübingen, Germany
Naiba Nabieva

⁴Erlangen University Hospital, Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany
Friedrich Overkamp

⁶OncoConsult Hamburg GmbH, Hamburg, Germany
Hans-Christian Kolberg

⁷Department of Gynecology and Obstetrics, Marienhospital Bottrop, Bottrop, Germany
Peyman Hadji

⁸Department of Bone Oncology, Nordwest Hospital, Frankfurt, Germany
Hans Tesch

⁹Oncology Practice at Bethanien Hospital Frankfurt, Frankfurt, Germany
Achim Wöckel

¹⁰Department of Gynecology and Obstetrics, University Hospital Würzburg, Würzburg, Germany
Johannes Ettl

¹¹Department of Obstetrics and Gynecology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany
Diana Lüftner

¹²Charité University Hospital, Berlin, Campus Benjamin Franklin, Department of Hematology, Oncology and Tumour Immunology, Berlin, Germany
Markus Wallwiener

³Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany
Volkmar Müller

¹³Department of Gynecology, Hamburg-Eppendorf University Medical Center, Hamburg, Germany
Matthias W. Beckmann

⁴Erlangen University Hospital, Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany
Erik Belleville

¹⁴ClinSol GmbH & Co KG, Würzburg, Germany
Diethelm Wallwiener

¹Department of Obstetrics and Gynecology, University of Tübingen, Tübingen, Germany
Sara Y. Brucker

¹Department of Obstetrics and Gynecology, University of Tübingen, Tübingen, Germany
Peter A. Fasching

⁴Erlangen University Hospital, Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany
Tanja N. Fehm

¹⁵Department of Gynecology and Obstetrics, University Hospital Düsseldorf, Düsseldorf, Germany
Florian Schütz

³Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany

Abstract

Zusammenfassung

In dieser Übersichtsarbeit wird dargestellt, wie neue Therapien oder neue Aspekte etablierter Therapien in Zusammenhang mit neuesten, aktuellen Erkenntnissen stehen. Neoadjuvanz, Lokaltherapie, neue Aspekte der Systemtherapie und Prognose- sowie Prädiktivfaktoren werden beleuchtet. In der Neoadjuvanz ist nach wie vor der Zusammenhang zwischen pCR und Prognose von Interesse, ebenso wie neue molekulare Prädiktoren für neue Therapien wie CDK4/6-Inhibitoren zu identifizieren. Bei der operativen Behandlung wird weiter nach einer Reduktion der Aggressivität gestrebt. Insbesondere das duktale Carcinoma in situ muss dafür noch besser verstanden werden. Bei den Systemtherapien wächst die Datenlage zum Verständnis der besten Kombinationen und Therapieabläufe für bestehende Therapieverfahren. Letztendlich muss mithilfe von Prognose- und Prädiktivfaktoren vermieden werden, dass Übertherapien stattfinden und nur die Patientin spezifische Therapien erhält, welche bei dieser individuellen Patientin eine nachgewiesene Wirksamkeit mit wenig Nebenwirkungen haben.

Schlüsselwörter

Mammakarzinom - Behandlung - Lokalrezidiv - Studien - Prognosefaktoren - Prädiktivfaktoren

Full Text

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