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Semin Thromb Hemost
DOI: 10.1055/s-0044-1779632
Review Article

Tranexamic Acid: An Evergreen Hemostatic Agent

Massimo Franchini
1   Department of Transfusion Medicine and Hematology, Carlo Poma Hospital, Mantua, Italy
,
Daniele Focosi
2   North-Western Tuscany Blood Bank, Pisa University Hospital, Italy
,
Pier Mannuccio Mannucci
3   Fondazione IRCCS Ca' Granda-Ospedale Maggiore Policlinico and University of Milan, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Milan, Italy
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Abstract

Tranexamic acid (TXA) is an important antifibrinolytic agent, which inhibits plasminogen activation and fibrinolysis. Several controlled randomized trials have investigated the role of TXA in preventing or decreasing blood loss across different surgical interventions or medical conditions characterized by excessive bleeding, consistently documenting its effectiveness and safety. Although the first clinical use of TXA dates back to more than 60 years ago, TXA remains the focus of intense research. This narrative review summarizes the more recent results and indications on the clinical use of TXA.

Keywords

tranexamic acid - antifibrinolytic agent - bleeding - thrombosis


Publication History

Article published online:
09 February 2024

© 2024. Thieme. All rights reserved.

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