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CC BY-NC-ND 4.0 · International Journal of Epilepsy
DOI: 10.1055/s-0044-1779694
Review Article

Antisense Molecules in Epilepsy—A Neuropharmacological Educational Review

Jefry Winner George Stephen 
1   Department of Pharmacology, Jawaharlal Institute of Postgraduate Medical Education & Research, Puducherry, India
,
Jesiha George Stephen
2   PSG Institute of Medical Science and Research, Coimbatore, India
,
Mohammed Ali
3   Department of Neurology, Jawaharlal Institute of Postgraduate Medical Education & Research, Puducherry, India
,
Ashwin Kumar
1   Department of Pharmacology, Jawaharlal Institute of Postgraduate Medical Education & Research, Puducherry, India
,
Susanna Jose
4   Veeda Clinical Research Institute, Mumbai, India
› Author Affiliations
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Abstract

Epilepsy is a common neurological disorder. Epilepsy has many therapeutic options, the popular one being antiseizure medications. A good proportion of patients always responds well to the existing treatment modalities. But some patients develop resistant epilepsy, and treating them can be challenging with the current treatment; such scenarios are encountered frequently in patients, especially those under treatment for long-term as well as specific syndromes and channelopathies. Resistant epilepsy warrants the need to develop newer therapeutics for better treatment outcomes, and antisense oligonucleotides (ASOs) are one among them. Our review discusses the more recent startups called ASOs in the context of epilepsy therapeutics.

Keywords

Lafora disease - tRNA-based therapeutic - seizure


Publication History

Article published online:
04 March 2024

© 2024. Indian Epilepsy Society. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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