Prenatal Diagnosis of Renal Rhabdoid Tumor: A Rare Malignant Neoplasm

Abstract

Rhabdoid tumors of the kidney are highly lethal malignancies of infancy. We report the prenatal detection of this renal tumor in a fetus in the third trimester of pregnancy. Ultrasonologically, the tumor appeared as a large mass in the left renal area associated with severe polyhydramnios. Though the sonographic features alone did not allow distinction from a benign lesion, tumor extension into the subcutaneous plane favored the possibility of a malignant renal tumor and this was confirmed postnatally on histopathology.

Keywords

rhabdoid tumor - rare renal neoplasm - malignant renal tumor - prenatal diagnosis - prenatal ultrasound

Informed Consent

Written informed consent was obtained from the patients for participation and publication of this study.

Ethical Approval

This was in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Authors' Contributions

All authors contributed to the study's conception and design. All authors have read and approved the final manuscript.

Publikationsverlauf

Artikel online veröffentlicht:
10. April 2024

• References

• 1 Chen WY, Lin CN, Chao CS. et al. Prenatal diagnosis of congenital mesoblastic nephroma in mid-second trimester by sonography and magnetic resonance imaging. Prenat Diagn 2003; 23 (11) 927-931
• 2 Chung CJ, Lorenzo R, Rayder S. et al. Rhabdoid tumors of the kidney in children: CT findings. AJR Am J Roentgenol 1995; 164 (03) 697-700
• 3 Chung CJ, Cammoun D, Munden M. Rhabdoid tumor of the kidney presenting as an abdominal mass in a newborn. Pediatr Radiol 1990; 20 (07) 562-563
• 4 Schenone CV, King A, Castro E, Ketwaroo P, Donepudi R, Sanz-Cortes M. Prenatal detection of disseminated extrarenal malignant rhabdoid tumor with placental metastases. Ultrasound Obstet Gynecol 2021; 57 (06) 1008-1010
• 5 Wagner L, Hill DA, Fuller C. et al. Treatment of metastatic rhabdoid tumor of the kidney. J Pediatr Hematol Oncol 2002; 24 (05) 385-388
• 6 Beckwith JB, Palmer NF. Histopathology and prognosis of Wilms tumor results from the first national Wilms' tumor study. Cancer 1978; 41 (05) 1937-1948
• 7 Hindryckx A, De Catte L. Prenatal diagnosis of congenital renal and urinary tract malformations. Facts Views Vis ObGyn 2011; 3 (03) 165-174
• 8 Mata RP, Alves T, Figueiredo A, Santos A. Prenatal diagnosis of congenital mesoblastic nephroma: a case with poor prognosis. BMJ Case Rep 2019; 12 (08) e230297
• 9 Sarin YK, Rahul SK, Sinha S, Khurana N, Ramji S. Antenatally diagnosed Wilms' tumour. J Neonatal Surg 2014; 3 (01) 8
• 10 Vadeyar S, Ramsay M, James D, O'Neill D. Prenatal diagnosis of congenital Wilms' tumor (nephroblastoma) presenting as fetal hydrops. Ultrasound Obstet Gynecol 2000; 16 (01) 80-83
• 11 Goldstein I, Shoshani G, Ben-Harus E, Sujov P. Prenatal diagnosis of congenital mesoblastic nephroma. Ultrasound Obstet Gynecol 2002; 19 (02) 209-211
• 12 Geirsson RT, Ricketts NE, Taylor DJ, Coghill S. Prenatal appearance of a mesoblastic nephroma associated with polyhydramnios. J Clin Ultrasound 1985; 13 (07) 488-490
• 13 Howey DD, Farrell EE, Sholl J, Goldschmidt R, Sherman J, Hageman JR. Congenital mesoblastic nephroma: prenatal ultrasonic findings and surgical excision in a very-low-birth-weight infant. J Clin Ultrasound 1985; 13 (07) 506-508
• 14 Fung TY, Fung YM, Ng PC, Yeung CK, Chang MZ. Polyhydramnios and hypercalcemia associated with congenital mesoblastic nephroma: case report and a new appraisal. Obstet Gynecol 1995; 85 (5 Pt 2): 815-817
• 15 Vujanić GM, Sandstedt B, Harms D, Boccon-Gibod L, Delemarre JF. Rhabdoid tumour of the kidney: a clinicopathological study of 22 patients from the International Society of Paediatric Oncology (SIOP) nephroblastoma file. Histopathology 1996; 28 (04) 333-340
• 16 White FV, Dehner LP, Belchis DA. et al. Congenital disseminated malignant rhabdoid tumor: a distinct clinicopathologic entity demonstrating abnormalities of chromosome 22q11. Am J Surg Pathol 1999; 23 (03) 249-256
• 17 Ohyama M, Ijiri R, Tanaka Y. et al. Congenital primitive epithelial tumor of the liver showing focal rhabdoid features, placental involvement, and clinical features mimicking multifocal hemangioma or stage 4S neuroblastoma. Hum Pathol 2000; 31 (02) 259-263
• 18 Staehelin F, Bissig H, Hösli I. et al. Inv(11)(p13p15) and myf-3(MyoD1) in a malignant extrarenal rhabdoid tumor of a premature newborn. Pediatr Res 2000; 48 (04) 463-467
• 19 Hösli I, Holzgreve W, Danzer E, Tercanli S. Two case reports of rare fetal tumors: an indication for surface rendering?. Ultrasound Obstet Gynecol 2001; 17 (06) 522-526
• 20 Leader J, Carlan SJ, Blum J. Congenital malignant extrarenal rhabdoid tumor: prenatal ultrasound findings. Obstet Gynecol 2002; 99 (5 Pt 2): 949-951
• 21 Fuchs IB, Henrich W, Kalache KD, Lippek F, Dudenhausen JW. Prenatal sonographic features of a rhabdoid tumor of the kidney. Ultrasound Obstet Gynecol 2004; 23 (04) 407-410
• 22 Kwon JY, Park KI, Lee KS, Yang WI, Kim YH. Prenatal detection of congenital malignant extrarenal rhabdoid tumor primarily involving the right upper extremity that ruptured in utero. Prenat Diagn 2009; 29 (08) 819-821
• 23 Joueidi Y, Rousselin A, Rozel C. et al. Ultrasound presentation of a disseminated fetal and neonatal rhabdoid tumor. Case Rep Obstet Gynecol 2018; 6073204
• 24 Trabelsi F, Bouthour H, Bustame S. Rhabdoid tumor of the kidney: a new case of prenatal diagnosis with metastases immediately. Med Sur Urol. 2016; 5 (167) 2
• 25 Finetti MA, Grabovska Y, Bailey S, Williamson D. Translational genomics of malignant rhabdoid tumours: current impact and future possibilities. Semin Cancer Biol 2020; 61: 30-41