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CC BY-NC-ND 4.0 · Sleep Sci
DOI: 10.1055/s-0044-1780502
Case Report

Treatment Approaches to Myasthenia Gravis and Obstructive Sleep Apnea: Case Report

Sergio Giamas Iafigliola 
1   Departament of Pediatrics, Escola Paulista de Medicina, Universidade Federal de São Paulo (Unifesp), São Paulo, SP, Brazil
,
Thais Moura Guimarães
2   Departamento de Psicobiologia, Escola Paulista de Medicina, Universidade Federal de São Paulo (Unifesp), São Paulo, SP, Brazil
,
Vânia D'Almeida
1   Departament of Pediatrics, Escola Paulista de Medicina, Universidade Federal de São Paulo (Unifesp), São Paulo, SP, Brazil
2   Departamento de Psicobiologia, Escola Paulista de Medicina, Universidade Federal de São Paulo (Unifesp), São Paulo, SP, Brazil
,
Dalva Poyares
2   Departamento de Psicobiologia, Escola Paulista de Medicina, Universidade Federal de São Paulo (Unifesp), São Paulo, SP, Brazil
,
Cibele Dal-Fabbro
3   Research Center of Le Centre Intégré Universitaire de Santé et de Services Sociaux (CIUSSS) du Nord-de-l'île-de-Montréal, Université de Montreal, Montreal, Quebec, Canada
4   Faculty of Dentistry, Université de Montreal, Montreal, Quebec, Canada
,
Sergio Tufik
2   Departamento de Psicobiologia, Escola Paulista de Medicina, Universidade Federal de São Paulo (Unifesp), São Paulo, SP, Brazil
,
Gustavo A. Moreira
1   Departament of Pediatrics, Escola Paulista de Medicina, Universidade Federal de São Paulo (Unifesp), São Paulo, SP, Brazil
2   Departamento de Psicobiologia, Escola Paulista de Medicina, Universidade Federal de São Paulo (Unifesp), São Paulo, SP, Brazil
› Author Affiliations Funding Source Our studies are supported by the Associação Fundo de Incentivo à Pesquisa (AFIP). S.T. receives a grant from the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq).
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Abstract

Myasthenia gravis (MG) is a chronic autoimmune disease characterized by progressive weakness and skeletal muscle fatigue due to the destruction of acetylcholine receptors, causing an abnormality in the synaptic junction between innervation and muscle fibers. The treatment of patients with MG and obstructive sleep apnea (OSA) is positive pressure in the airway; however, the lack of adherence to the protocol can lead to increased morbidity. A known alternative treatment for OSA is the mandibular advancement device (MAD). The objective of the present report is to describe an emblematic case of a 50-year-old male patient with MG with sleep complaints and documented OSA, and his response to different treatment approaches.

Keywords

mandibular advancement device - myasthenia gravis - obstructive sleep apnea


Publication History

Received: 12 April 2023

Accepted: 08 November 2023

Article published online:
15 May 2024

© 2024. Brazilian Sleep Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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