CC BY-NC-ND 4.0 · Journal of Fetal Medicine 2023; 10(04): 175-181
DOI: 10.1055/s-0044-1782222
SFM Practice Guidelines

SFM Fetal Therapy Practice Guidelines: Fetal Cystoscopic Laser Ablation

Gourisankar Rudrapal
1   Division of Fetal Medicine & Perinatology, Department of Obstetrics & Gynecology, Amrita Institute of Medical Sciences, AIMS Ponekkara, Kochi, Kerala, India
,
Adinarayan Makkam
1   Division of Fetal Medicine & Perinatology, Department of Obstetrics & Gynecology, Amrita Institute of Medical Sciences, AIMS Ponekkara, Kochi, Kerala, India
,
1   Division of Fetal Medicine & Perinatology, Department of Obstetrics & Gynecology, Amrita Institute of Medical Sciences, AIMS Ponekkara, Kochi, Kerala, India
› Author Affiliations
Funding None.

Abstract

Fetal lower urinary tract obstruction (LUTO) in a male fetus could cause detrimental effects to the KUB (kidney, ureter, and bladder) system from back-pressure changes as well as to the lungs from reduced amniotic fluid. In a carefully selected case where the obstruction causes progressive damage, a therapeutic intervention could be lifesaving. In utero vesico-amniotic shunting has been shown to improve perinatal pulmonary survival, but evidence on improvement of renal outcomes with this procedure is lacking. More recently, fetal cystoscopic laser fulguration has been shown to be beneficial in longer-term survival and renal outcomes. These interventions carry significant risk, and therefore patient selection and optimal timing are key. This guideline lists the intricacies of patient selection, relevant counseling points and procedural details.



Publication History

Article published online:
01 April 2024

© 2024. Society of Fetal Medicine. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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  • Suggested Reading

  • 1 Farrugia MK. Fetal bladder outlet obstruction: embryopathology, in utero intervention and outcome. J Pediatr Urol 2016; 12 (05) 296-303
  • 2 Nguyen HT, Herndon CDA, Cooper C. et al. The Society for Fetal Urology consensus statement on the evaluation and management of antenatal hydronephrosis. J Pediatr Urol 2010; 6 (03) 212-231
  • 3 Morris RK, Quinlan-Jones E, Kilby MD, Khan KS. Systematic review of accuracy of fetal urine analysis to predict poor postnatal renal function in cases of congenital urinary tract obstruction. Prenat Diagn 2007; 27 (10) 900-911
  • 4 Ruano R, Dunn T, Braun MC, Angelo JR, Safdar A. Lower urinary tract obstruction: fetal intervention based on prenatal staging. Pediatr Nephrol 2017; 32 (10) 1871-1878
  • 5 Morris RK, Middleton LJ, Malin GL. et al; PLUTO Collaborative Group. Outcome in fetal lower urinary tract obstruction: a prospective registry study. Ultrasound Obstet Gynecol 2015; 46 (04) 424-431
  • 6 Nassr AA, Shazly SAM, Abdelmagied AM. et al. Effectiveness of vesicoamniotic shunt in fetuses with congenital lower urinary tract obstruction: an updated systematic review and meta-analysis. Ultrasound Obstet Gynecol 2017; 49 (06) 696-703
  • 7 Morris RK, Malin GL, Quinlan-Jones E. et al; Percutaneous vesicoamniotic shunting in Lower Urinary Tract Obstruction (PLUTO) Collaborative Group. Percutaneous vesicoamniotic shunting versus conservative management for fetal lower urinary tract obstruction (PLUTO): a randomised trial. Lancet 2013; 382 (9903) 1496-1506
  • 8 Morris RK, Ruano R, Kilby MD. Effectiveness of fetal cystoscopy as a diagnostic and therapeutic intervention for lower urinary tract obstruction: a systematic review. Ultrasound Obstet Gynecol 2011; 37 (06) 629-637
  • 9 Martínez JM, Masoller N, Devlieger R. et al. Laser ablation of posterior urethral valves by fetal cystoscopy. Fetal Diagn Ther 2015; 37 (04) 267-273