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Semin Neurol
DOI: 10.1055/s-0044-1785502
Review Article

Prognostic Implications of Early Prediction in Posttraumatic Epilepsy

Yilun Chen
1   Department of Neurology, Yale University, New Haven, Connecticut
,
Stefanie P. Cappucci
1   Department of Neurology, Yale University, New Haven, Connecticut
,
Jennifer A. Kim
1   Department of Neurology, Yale University, New Haven, Connecticut
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Abstract

Posttraumatic epilepsy (PTE) is a complication of traumatic brain injury that can increase morbidity, but predicting which patients may develop PTE remains a challenge. Much work has been done to identify a variety of risk factors and biomarkers, or a combination thereof, for patients at highest risk of PTE. However, several issues have hampered progress toward fully adapted PTE models. Such issues include the need for models that are well-validated, cost-effective, and account for competing outcomes like death. Additionally, while an accurate PTE prediction model can provide quantitative prognostic information, how such information is communicated to inform shared decision-making and treatment strategies requires consideration of an individual patient's clinical trajectory and unique values, especially given the current absence of direct anti-epileptogenic treatments. Future work exploring approaches integrating individualized communication of prediction model results are needed.

Keywords

posttraumatic epilepsy - risk factors - biomarkers - prediction models - prognostication


Publication History

Article published online:
15 April 2024

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