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DOI: 10.1055/s-0044-1786880
A Prospective Study on the Use of Deep Inspiration Breath-Hold Technique in External Beam Radiotherapy for Breast Cancer
Funding None.
Abstract
Background
Breast cancer is the most common cancer and the leading cause of death in women. The deep inspiration breath-hold (DIBH) technique helps reduce the dose received by the heart and lungs in breast cancers during adjuvant radiotherapy (RT). We present the dosimetry of heart and lungs with DIBH technique, reproducibility, and ease of execution.
Materials and Methods
This is a prospective study among breast cancer patients planned for adjuvant RT following either breast conservation or mastectomy. Patients received adjuvant RT to a dose of 42.5 Gy/16 Fr to the chest wall/whole breast followed by a boost of 10 Gy/5 Fr for breast conservation surgery patients with either three-dimensional conformal RT or volumetric modulated arc therapy technique. The dosimetric parameters such as lung mean dose, heart mean dose, and V25 Gy were compared between DIBH and free-breathing (FB) scans. Data were analyzed using SPSS software, and p-value <0.05 was considered statistically significant.
Results
The study was conducted from September 2018 to August 2020, and 32 patients were included. The compliance to the DIBH technique was good. The dose received by ipsilateral lung V20 (17 vs. 25%) and mean dose (9 vs. 12 Gy) were significantly lower in DIBH compared with FB (p < 0.001). The V5 (31 vs. 15%), V25 (9 vs. 2%), and mean dose (7 vs. 3.3 Gy) to the heart were much higher in FB compared with DIBH (p < 0.001).
Conclusion
DIBH-based RT treatment delivery for breast cancer patients requiring adjuvant RT showed good compliance and offers a significant reduction in radiation dose to the heart and lung.
Keywords
breast cancer - adjuvant radiotherapy - deep inspiration breath hold - radiation - toxicitiesAuthors' Contribution
There is equal contribution from both first authors hence, put as first coauthors. As well as, equal contribution from both corresponding authors, hence as corresponding coauthors. N.J. and K.S. conceptualized, designed, and analyzed the study. J.N.P. and S.L. prepared the manuscript. All authors reviewed the manuscript.
Ethical Approval
This study was performed in line with the Declaration of Helsinki; approval was obtained from the Institutional Ethics Committee (IEC no.: 632/2018).
Conference Presentation
WALTCON 2023.
Informed Consent
Informed consent was taken from the participants for participation in the study.
* These authors are co-first authors.
Publication History
Received: 11 November 2023
Accepted: 16 April 2024
Article published online:
13 May 2024
© 2024. MedIntel Services Pvt Ltd. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)
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