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CC BY 4.0 · Semin Respir Crit Care Med 2024; 45(04): 469-478
DOI: 10.1055/s-0044-1787554
DOI: 10.1055/s-0044-1787554
Review Article
Dysregulation of Host–Pathogen Interactions in Sepsis: Host-Related Factors
Funding S.C.M.J. is supported by a grant from The Dutch Ministery of Economic Affairs & Health Holland, TKI-program Life Sciences & Health (project DETECT-SEPSIS).
Abstract
Sepsis stands as a prominent contributor to sickness and death on a global scale. The most current consensus definition characterizes sepsis as a life-threatening organ dysfunction stemming from an imbalanced host response to infection. This definition does not capture the intricate array of immune processes at play in sepsis, marked by simultaneous states of heightened inflammation and immune suppression. This overview delves into the immune-related processes of sepsis, elaborating about mechanisms involved in hyperinflammation and immune suppression. Moreover, we discuss stratification of patients with sepsis based on their immune profiles and how this could impact future sepsis management.
Publikationsverlauf
Artikel online veröffentlicht:
01. Juli 2024
© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)
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