PDF herunterladen
Open Access
CC BY 4.0 · Libyan International Medical University Journal 2024; 09(02): 056-061
DOI: 10.1055/s-0044-1788715
Original Article

Corneal Endothelial Cell Density and Morphology in Healthy Libyan Eyes

Authors

  • Osama R. Elmsalaty

    1   Ophthalmology Department, Faculty of Medicine, University of Benghazi, Benghazi, Libya

  • Samar A. Bukhatwa 

    1   Ophthalmology Department, Faculty of Medicine, University of Benghazi, Benghazi, Libya
Weitere Informationen
Auch verfügbar auf
  Lizenzen und Reprints
Preview

Abstract

Background Endothelial cell density and morphology vary across ethnic groups.

Aim This article investigates the corneal endothelial cell density and morphology in healthy Libyan eyes.

Methods A 3-month cross-sectional observational study was conducted at Benghazi Teaching Eye Hospital, involving 198 eyes of 100 healthy Libyan participants. The noncontact Topcon specular microscope (SP-1P model) was used to assess the following parameters: the mean central corneal thickness (CCT), the mean cell density (MCD), the mean coefficient of variation (CV%), and the mean percentage of the hexagonal cell (Hex [%]). The variables were analyzed in relation to age and gender using the Statistical Package for the Social Sciences (SPSS version 25.0)

Results The mean age of participants in this study was 47.4 ± 13.8 years (range 21–75 years). The mean CCT was 516.45 ± 43.04 μm, the MCD was 2664.30 ± 371.26 cells/mm2, the mean CV% was 32.3% ± 3.7, and the mean Hex (%) was 52.8% ± 9.6. There was no statistical difference in the age, CCT, and MCD across genders. Whereas CV (%) and Hex (%) showed significant gender differences (p < 0.01 for both). There was a significant negative weak correlation between CCT (r = –0.10) and age, as well as a significant negative moderate correlation between MCD and Hex (%) with age (r = –0.36 and r = –0.31, respectively). CV% exhibited a significant, moderately positive association with age (r = 0.35). The higher endothelial cell loss rate of 8.4% was in the third decade of life whereas other age groups ranged between 1.1 and 2.7%.

Conclusion The normative data for the endothelium of Libyan eyes are reported, which can be used as a baseline for future studies.

Zoom

Keywords

corneal endothelium - Libyan eyes - morphology - normative data - specular microscopy

* The study was carried out following the Helsinki Declaration, and the subjects signed an informed consent form after being informed about the study.




Publikationsverlauf

Eingereicht: 29. Mai 2024

Angenommen: 02. Juli 2024

Artikel online veröffentlicht:
12. August 2024

© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India