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CC BY-NC-ND 4.0 · Asian J Neurosurg 2025; 20(01): 190-195
DOI: 10.1055/s-0044-1791998
Clinical Case Study

Non-Neoformans Cryptococcal Infections in the Post-Coronavirus Disease-19 (COVID-19) Era: Are We Ready to Face the Emerging Challenge?

Authors

  • Umayra Fatima

    1   Department of Dentistry, Princess Esra Hospital, Deccan College of Medical Sciences, Hyderabad, Telangana, India

  • Hina Ahmed

    2   Department of Conservative Dental Sciences, Ibn Sina National College for Medical Studies, Jeddah, Kingdom of Saudi Arabia

  • Gautam Singh

    2   Department of Conservative Dental Sciences, Ibn Sina National College for Medical Studies, Jeddah, Kingdom of Saudi Arabia

  • K.Y. Giri

    3   Department of Oral and Maxillofacial Surgery, Drs Sudha and Nageswara Rao Siddhartha Institute of Dental Sciences, Gannavaram, Andhra Pradesh, India

  • Md. Sania Azmi

    4   Department of Oral and Maxillofacial Pathology, Care Dental College, Guntur, Andhra Pradesh, India

  • Archana Meenakshi

    5   Department of Periodontology, Ragas Dental College and Hospital, Chennai, Tamil Nadu, India

  • Suresh Babu Jandrajupalli

    6   Division of Periodontology, Department of Preventive Dental Sciences, College of Dentistry, University of Ha'il, Ha'il, Kingdom of Saudi Arabia

  • Swarnalatha Chandolu

    6   Division of Periodontology, Department of Preventive Dental Sciences, College of Dentistry, University of Ha'il, Ha'il, Kingdom of Saudi Arabia

  • Abhishek Singh Nayyar 

    7   Department of Oral Medicine and Radiology, Saraswati Dhanwantari Dental College and Hospital and Post-graduate Research Institute, Parbhani, Maharashtra, India
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Abstract

Coronaviruses are a large group of viruses that infect animals as well as humans, while it is also suggested that, rarely, coronaviruses that infect animals can evolve and infect humans. Current evidence suggests that severe acute respiratory syndrome (SARS) coronavirus-2 leads to coronavirus disease-19 (COVID-19), the respiratory illness responsible for COVID-19 pandemic, while it has a zoonotic origin, closely related to the bat-origin SARS-like coronavirus. Also, as per the current knowledge, the disease may induce significant and persistent lymphopenia which in turn may increase the risk for various opportunistic infections. Cryptococcus laurentii is one such rare, but serious fungal infection which has been reported in post-COVID-19 disease and is a rising cause of concern since it can turn out to be fatal. The infection is caused by a non-neoformans rare human pathogen. The present case report describes the case of a 45-years old male patient who reported to the Outpatient Department (OPD) for a routine dental complaint with a grossly destructed tooth in left lower back tooth region due to extensive carious involvement, while, simultaneously, presenting with fever since 5 days in the post-COVID-19 phase, and was later diagnosed as being positive for C. laurentii infection on urine culture sensitivity test.

Keywords

coronaviruses - non-neoformans cryptococcal infections - Cryptococcus laurentii - coronavirus disease-19

Authors' Contributions

All authors contributed significantly to this work across multiple areas. They were involved in developing the concepts, designing the structure of the case report format, as well as in defining the intellectual content. Each contributed to the literature search, as well as in the acquisition and analysis of patient-related data. The manuscript was prepared with contributions from all authors, who also played key roles in editing and reviewing the final draft. Finally, all authors share responsibility as guarantors, ensuring the accuracy and integrity of the work.




Publication History

Article published online:
04 November 2024

© 2024. Asian Congress of Neurological Surgeons. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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