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DOI: 10.1055/s-0044-1795162
Persistent Generalized Lymphadenopathy: A Diagnostic Conundrum—Case Report and Review of Literature
Authors
Funding None.
Abstract
Generalized lymphadenopathy is a nonspecific sign with heterogenous etiology including infective, inflammatory, and malignant causes. We present the case of a child who presented with generalized lymphadenopathy, involving the cervical, axillary, mediastinal, and inguinal groups, along with recurring fever, tonsillar enlargement, and parotid swelling for 2 years. She had coexisting undernutrition and hepatosplenomegaly on examination. After ruling out common infective causes like tuberculosis, autoimmune and neoplastic conditions were considered. The diagnosis was made by histopathology of the axillary node biopsy, which revealed characteristic features of Rosai–Dorfman disease (RDD). She was started on oral steroids but was lost to follow-up after 6 months. We report this case to emphasize that RDD, a subtype of non-Langerhans histiocytosis, should be considered as a differential in young patients with persistent generalized lymphadenopathy.
Patient's Consent
Informed consent was obtained from the parents of the child for publication of the clinical data.
Authors' Contributions
M.M., V.S., N.S., and K.K. managed the patient, reviewed the literature, and drafted the manuscript. B.R., A.M., A.S., and S.M. managed the patient, reviewed the manuscript, and critically revised the manuscript. All the authors contributed to reviewing the literature, drafting the manuscript, and approving the final version of the manuscript. A.S. shall act as the guarantor and corresponding author of the article.
Publication History
Article published online:
30 December 2024
© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)
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