Open Access
CC BY 4.0 · Brazilian Journal of Oncology 2019; 15
DOI: 10.1055/s-0044-1798216
PO IMPRESSO
TEMÁRIO: RADIOTERAPIA (SUBMISSÃO PARA O XXI CONGRESSO DA SOCIEDADE BRASILEIRA DE RADIOTERAPIA) CÓDIGO

WAITING TIME FOR THE BEGINNING OF BRAQUITERAPIA AND SURVIVAL IN FIVE YEARS OF WOMEN WITH CERVIX CANCER TREATED AT A RIO DE JANEIRO ONCOLOGICAL REFERENCE CENTER IN 2012

Authors

  • Juliana Chaves Carneiro Carvalho

    1   Instituto Nacional de Câncer RJ

  • Alexandre Brito

    2   Universidade Federal do Rio de Janeiro - IESC

  • Rachele Grazziotin Reisner

    1   Instituto Nacional de Câncer RJ

  • Elizabeth Nakano

    1   Instituto Nacional de Câncer RJ
Weitere Informationen
  Alle Artikel dieser Rubrik

Introduction: Cervical cancer is a curable public health problem, especially with early diagnosis and immediate treatment. In Brazil, it is still very prevalent and has a high mortality rate, usually due to late diagnosis and difficulty in accessing therapies. Delay in starting brachytherapy (BT) further increases the total treatment time. Objective: To analyze the 5-year survival (SV) of locally advanced cervical cancer considering the waiting time between chemoradiotherapy (CRT) and BT in a cohort of patients seen at a referral cancer hospital in the city of Rio de Janeiro. Methods: Retrospective evaluation, including 166 women with stage IB, IIA and B, IIIA and B and IVA uterine cervix cancer treated with CRT and BT during 2012. The information was obtained from medical records, as well as on bases. secondary data provided by the Hospital Registry of Cancer and the Mortality Information System. Association between waiting time (in days) for the onset of CRT and death was estimated by hazard ratios (HR), with their respective confidence intervals (CI 95%) from Cox regression, adjusted for prognostic covariates (age, education, histological type, staging, hemoglobin dosage at baseline, presence of comorbidities, duration of CRT, and BT. Results: Total mean duration of treatment was 183 days (SD = 67.7 Pelvic radiotherapy (RT) lasted an average of 41 days (SD = 10.1) and CRT lasted 16.4 days (SD = 5.9). The longest waiting period was between RT and CRT., which averaged 125.7 days (SD: 66.9). There were 85 (51%) deaths from cervical cancer in this cohort. The estimated 5-year SV was 45% among women waiting up to 115 days. for CRT and 39% for those waiting more than 115 days, however there was no statistically significant difference and 5-year survival of these two periods (log Rank test: p = 0.65). The adjusted risk ratio was also not statistically significant (HR: 0.999 and CI 95%: 0.99-1.00). Conclusion: In the cohort studied, with prolonged waiting time for CRT, there was no difference in survival according to this waiting time. Further studies are needed to evaluate the effect of delayed CRT on survival.



Publikationsverlauf

Artikel online veröffentlicht:
23. Oktober 2019

© 2019. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution 4.0 International License, permitting copying and reproduction so long as the original work is given appropriate credit (https://creativecommons.org/licenses/by/4.0/)

Thieme Revinter Publicações Ltda.
Rua do Matoso 170, Rio de Janeiro, RJ, CEP 20270-135, Brazil

Bibliographical Record
Juliana Chaves Carneiro Carvalho, Alexandre Brito, Rachele Grazziotin Reisner, Elizabeth Nakano. WAITING TIME FOR THE BEGINNING OF BRAQUITERAPIA AND SURVIVAL IN FIVE YEARS OF WOMEN WITH CERVIX CANCER TREATED AT A RIO DE JANEIRO ONCOLOGICAL REFERENCE CENTER IN 2012. Brazilian Journal of Oncology 2019; 15.
DOI: 10.1055/s-0044-1798216