Hamostaseologie 2025; 45(S 01): S26-S27
DOI: 10.1055/s-0044-1801580
Abstracts
Topics
T-05 Crosstalks between hemostasis and other systems

Intensive lifestyle intervention on thrombin generation in individuals at high risk for type 2 diabetes

Authors

  • S Hörber

    1   University Hospital Tübingen, Tübingen, Germany

  • J Machann

    1   University Hospital Tübingen, Tübingen, Germany

  • N Stefan

    1   University Hospital Tübingen, Tübingen, Germany

  • A Birkenfeld

    1   University Hospital Tübingen, Tübingen, Germany

  • R Wagner

    2   Institute for Clinical Diabetology, German Diabetes Center (DDZ), Leibniz Center for Diabetes Research at Heinrich-Heine University, Düsseldorf, Germany

  • M Heni

    3   University Hospital Ulm, Ulm, Germany

  • A Fritsche

    1   University Hospital Tübingen, Tübingen, Germany

  • A Peter

    1   University Hospital Tübingen, Tübingen, Germany
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Introduction: Prediabetes increases the risk of type 2 diabetes, cardiovascular disease, and mortality and is associated with a prothrombotic state. Therefore, we investigated the effect of an intensive lifestyle intervention on thrombin generation and elucidated underlying associations with metabolic variables in individuals at high risk for type 2 diabetes.

Method: The current analysis included 593 high-risk participants from the multicenter Prediabetes Lifestyle Intervention Study (PLIS). High-risk participants were randomized to a conventional or intensive lifestyle intervention group and characterized by reduced insulin secretion and/or insulin resistance and elevated liver fat content. Precise metabolic phenotyping was performed before and after the 1-year lifestyle intervention, including oral glucose tolerance testing, MRI-based determination of liver fat content and thrombin generation measurements. Associations and changes in thrombin generation with metabolic variables were evaluated.

Results: At baseline, higher endogenous thrombin potential was significantly associated with younger age, increased body weight and increased liver fat content. Of 593 high-risk participants, 280 were assigned to the conventional and 313 to the intensive lifestyle intervention group. During the intensive lifestyle intervention, thrombin generation parameters decreased significantly in the high-risk participants. Changes in thrombin generation markers were associated with changes in body weight and liver fat. In the conventional lifestyle intervention group, no significant changes in thrombin generation parameters were observed after the lifestyle intervention.

Conclusion: Thrombin generation markers are strongly associated with body weight and liver fat content in individuals at high risk for diabetes. Lifestyle intervention, especially intensive lifestyle intervention, is able to reduce endogenous thrombin potential, mediated by reductions in body weight and liver fat content. In addition to the known effects on diabetes risk, these findings highlight the beneficial effects of intensive lifestyle intervention on the hypercoagulable state in high-risk individuals.



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Artikel online veröffentlicht:
13. Februar 2025

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