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CC BY 4.0 · European Journal of General Dentistry 2025; 14(03): 354-360
DOI: 10.1055/s-0045-1802324
Original Article

Estimation of Salivary Creatine Kinase Level and Periodontal Health Status among Type II Diabetic and Nondiabetic Patients with Chronic Periodontitis

Ansam Mahdi Khalel 
1   Department of Oral Diagnosis, College of Dentistry, University of Kufa, Najaf, Iraq
,
Tabarak Sabah Abbas
1   Department of Oral Diagnosis, College of Dentistry, University of Kufa, Najaf, Iraq
,
Shatha Hameed Ali
1   Department of Oral Diagnosis, College of Dentistry, University of Kufa, Najaf, Iraq
,
Mustafa Basim Ali
1   Department of Oral Diagnosis, College of Dentistry, University of Kufa, Najaf, Iraq
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Abstract

Objectives

This study was conducted to determine the periodontal health status and the level of creatine kinase (CK) of the study and control groups and to correlate the level of this enzyme with clinical periodontal parameters in the study and control groups.

Materials and Methods

This study included 80 male participants aged 35 to 55 years, divided into four groups: poorly controlled type 2 diabetes mellitus with chronic periodontitis (G1), well-controlled type 2 diabetes mellitus with chronic periodontitis (G2), chronic periodontitis without diabetes (G3), and periodontally healthy controls (G4). Clinical periodontal parameters (plaque index, gingival index, periodontal pocket depth [PPD], and clinical attachment loss) and salivary CK levels (measured using enzyme-linked immunosorbent assay) were compared between groups.

Results

All clinical periodontal parameters and CK levels were highest in poorly controlled type 2 diabetes mellitus with chronic periodontitis patients, and the enzyme level revealed highly significant differences between all pairs of the study and control groups. There were nonsignificant weak correlations of CK with all clinical parameters in all groups except a significant moderate positive correlation with PPD in the nondiabetic with chronic periodontitis group.

Conclusion

It was concluded that poor glycemic control negatively impacts periodontal health status. CK is considered a good biochemical marker of periodontal tissue destruction and is useful in the diagnosis, monitoring, and management of periodontal diseases.

Keywords

chronic periodontitis - clinical periodontal parameters - creatine kinase - saliva - type 2 diabetes mellitus


Publication History

Article published online:
07 March 2025

© 2025. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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