Pneumologie 2025; 79(S 01): S118
DOI: 10.1055/s-0045-1804806
Abstracts
E1 – Kardiorespiratorische Interaktion und Pulmonale Hypertonie

Exercise training improves lung function in patients with pulmonary arterial hypertension (PAH)

S Haas
1   Thoraxklinik am Universitätsklinikum Heidelberg; Zentrum für Pulmonale Hypertonie
,
N Benjamin
2   Zentrum für Pulmonale Hypertonie; Thoraxklinik am Universitätsklinikum Heidelberg; Translational Lung Research Centre Heidelberg (Tlrc), German Centre for Lung Research (Dzl)
,
M Kieschke
1   Thoraxklinik am Universitätsklinikum Heidelberg; Zentrum für Pulmonale Hypertonie
,
P Xanthouli
3   Universitätsklinikum Heidelberg; Medizinische Klinik V; Rheumatologie
,
C Eichstaedt
4   Translational Lung Research Centre Heidelberg (Tlrc), German Centre for Lung Research (Dzl); Institut für Humangenetik, Universität Heidelberg
,
B Egenlauf
5   Thoraxklinik Universitätsklinik Heidelberg; Zentrum für Pulmonale Hypertonie; Pneumologie und Beatmungsmedizin, Thoraxklinik am Universitätsklinikum Heidelberg
,
S Harutyunova
6   Zentrum für Pulmonale Hypertonie, Thoraxklinik am Universitätsklinikum Heidelberg; Center for Pulmonary Hypertension, Thoraxklinik at Heidelberg University Hospital, Translational Lung Research Center Heidelberg (Tlrc), German Center for Lung Research (Dzl), Heidelberg; Pulmonale Hypertonie
,
E Grünig
7   Zentrum für Pulmonale Hypertonie; Thoraxklinik am Universitätsklinikum Heidelberg; Universitätsklinikum
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Objectives: Specialized exercise training was shown to improve exercise capacity and quality of life in patients with pulmonary arterial hypertension (PAH). The objective of this study was to investigate its effects on lung function parameters in PAH patients.

Methods: In this retrospective study clinical effects of a specialized exercise and respiratory training programme in PAH patients participating in training studies in Heidelberg were investigated. Data was derived from randomised controlled trials, controlled trials and cohort studies on exercise training of the study site. Follow-up data was collected after 3 weeks in-house and after 12 weeks of continuation of training at home. Control patients received the same clinical assessments without the rehabilitation training. Endpoints were changes in parameters of lung function, cardiopulmonary exercise testing, diffusion capacity and blood gas analysis.

Results: Data from 390 (control group: n=57, age 53.9±16.8 years, 56% female; training group: n=333, age 52.8±15.3 years, 72% female) patients were analysed. Patients receiving training showed significantly greater improvement in vital capacity (p=0.016) and partial oxygen pressure (p<0.05). Furthermore, peak oxygen uptake (p<0.001) and 6-minute walking distance (6MWD) (p<0.001) significantly improved in the training compared to the control group. Intragroup analysis demonstrated significant improvement in FEV1 (p=0.028), total lung capacity (TLC) (p=0.045), oxygen saturation (p=0.003), oxygen partial pressure (p=0.001), NT-proBNP (p<0.001) and 6MWD (p<0.001) between baseline and follow-up after 3 weeks. Positive results were confirmed after three months for 6MWD (p<0.001), peak oxygen consumption (p<0.001) and in trend for TLC (p=0.067).

Conclusion: This study could support the hypothesis that a specialized exercise training has a positive impact on lung function parameters in patients with PAH. Further studies are needed to elaborate long-term effects.

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Artikel online veröffentlicht:
18. März 2025

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