RSS-Feed abonnieren

DOI: 10.1055/s-0045-1808057
Postpartum Pseudoadenomatous Hypophysitis Simulating a Pituitary Macroadenoma: A Case Report and Literature Review

Abstract
Inflammatory hypothalamo-hypophyseal disorders are uncommon, representing only 1% of hypophyseal lesions. Among these, postpartum lymphocytic hypophysitis emerges as a particularly notable etiology. As a relatively recent entity, its recognition mandates a multidisciplinary approach to ensure preservation of compromised vital prognosis and amelioration of associated neuro-ophthalmologic and/or hypophyseal manifestations. We present a remarkable case of lymphocytic hypophysitis in a 32-year-old woman, unveiled during the postpartum period. Despite employing magnetic resonance imaging (MRI), preoperative diagnosis remained challenging. Surgical intervention became imperative due to progressive visual impairments. Postoperative course demonstrated favorable evolution, characterized by significant enhancement in visual acuity and normalization of cerebral MRI findings during follow-up.
Publikationsverlauf
Artikel online veröffentlicht:
24. April 2025
© 2025. Asian Congress of Neurological Surgeons. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)
Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India
-
References
- 1 Goudie RB, Pinkerton PH. Anterior hypophysitis and Hashimoto's disease in a young woman. J Pathol Bacteriol 1962; 83: 584-585
- 2 Gossain VV, Rovner DR. Primary hypothyroidism, pituitary insufficiency and pregnancy. A case report. J Reprod Med 1984; 29 (04) 284-288
- 3 Pholsena M, Young J, Couzinet B, Schaison G. Primary adrenal and thyroid insufficiencies associated with hypopituitarism: a diagnostic challenge. Clin Endocrinol (Oxf) 1994; 40 (05) 693-695
- 4 Beressi N, Cohen R, Beressi JP. et al. Pseudotumoral lymphocytic hypophysitis successfully treated by corticosteroid alone: first case report. Neurosurgery 1994; 35 (03) 505-508 , discussion 508
- 5 Reusch JE, Kleinschmidt-DeMasters BK, Lillehei KO, Rappe D, Gutierrez-Hartmann A. Preoperative diagnosis of lymphocytic hypophysitis (adenohypophysitis) unresponsive to short course dexamethasone: case report. Neurosurgery 1992; 30 (02) 268-272
- 6 Pechner MJA, Ludecker DK, Salger W. The anterior pituitary lobe in patients with cyctic craniopharyngioma. Three cases of associate lymphocytic hypophysitis. Acta Neurochir (Wien) 1994; 26: 34-43
- 7 Fedala NS, Chentli F, Meskine D, Haddam AEM. Les hypophysites: aspects cliniques et évolutifs. Ann Endocrinol (Paris) 2016; 77 (04) 329-371
- 8 Boudjeloud A, Sebti I, Bersali M, Saber KA. Hypophysite du post-partum: un piège diagnostic à propos d’un cas et revue de littérature. J Neurochir 2012; 15: 57
- 9 Hayashi H, Yamada K, Kuroki T. et al. Lymphocytic hypophysitis and pulmonary sarcoidosis. Report of a case. Am J Clin Pathol 1991; 95 (04) 506-511
- 10 Stelmach M, O'Day J. Rapid change in visual fields associated with suprasellar lymphocytic hypophysitis. J Clin Neuroophthalmol 1991; 11 (01) 19-24
- 11 Ahmadi J, Meyers GS, Segall HD, Sharma OP, Hinton DR. Lymphocytic adenohypophysitis: contrast-enhanced MR imaging in five cases. Radiology 1995; 195 (01) 30-34
- 12 Gutenberg A, Larsen J, Lupi I, Rohde V, Caturegli P. A radiologic score to distinguish autoimmune hypophysitis from nonsecreting pituitary adenoma preoperatively. AJNR Am J Neuroradiol 2009; 30 (09) 1766-1772
- 13 Leporati P, Landek-Salgado MA, Lupi I, Chiovato L, Caturegli P. IgG4-related hypophysitis: a new addition to the hypophysitis spectrum. J Clin Endocrinol Metab 2011; 96 (07) 1971-1980
- 14 Cosman F, Post KD, Holub DA, Wardlaw SL. Lymphocytic hypophysitis. Report of 3 new cases and review of the literature. Medicine (Baltimore) 1989; 68 (04) 240-256
- 15 Unlühizarci K, Bayram F, Colak R. et al. Distinct radiological and clinical appearance of lymphocytic hypophysitis. J Clin Endocrinol Metab 2001; 86 (05) 1861-1864
- 16 Stelmach M, O'Day J. Rapid change in visual fields associated with suprasellar lymphocytic hypophysitis. J Clin Neuroophthalmol 1991; 11 (01) 19-24
- 17 Levine SN, Benzel EC, Fowler MR, Shroyer III JV, Mirfakhraee M. Lymphocytic adenohypophysitis: clinical, radiological, and magnetic resonance imaging characterization. Neurosurgery 1988; 22 (05) 937-941
- 18 Shimono T, Yamaoka T, Nishimura K. et al. Lymphocytic hypophysitis presenting with diabetes insipidus: MR findings. Eur Radiol 1999; 9 (07) 1397-1400
- 19 Wild RA, Kepley M. Lymphocytic hypophysitis in a patient with amenorrhea and hyperprolactinemia. A case report. J Reprod Med 1986; 31 (03) 211-216
- 20 Mayfield RK, Levine JH, Gordon L, Powers J, Galbraith RM, Rawe SE. Lymphoid adenohypophysitis presenting as a pituitary tumor. Am J Med 1980; 69 (04) 619-623
- 21 Faje AT. et al. Comparing surgical decompression and corticosteroid therapy in lymphocytic hypophysitis: outcomes and long-term endocrine sequelae. J Clin Endocrinol Metab 2018; 103 (02) 567-575
- 22 Sato N. et al. Management of lymphocytic hypophysitis: a comparative study of surgical and conservative approaches. Pituitary 2021; 24 (04) 612-623