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DOI: 10.1055/s-0045-1808094
Clinical Audit of Denosumab Biosimilar for Aggressive GCT of Bone: A Tertiary Care Center Retrospective Analysis
Abstract
Objectives
Giant cell tumor of bone (GCTB) is a locally aggressive tumor with a high recurrence rate. Using denosumab or its biosimilar in a neoadjuvant setting can facilitate limb-preserving surgery and reduce recurrence rates, with minimal side effects.
Material and Methods
In this clinical audit, we retrospectively analyzed the impact of denosumab biosimilar (DB) on Campanacci grade 3 GCTB, the most aggressive form of these tumors.
Statistical Analysis
Means and standard deviations were used for normally distributed continuous variables, medians and ranges for nonnormal continuous variables, and percentages for categorical variables.
Results
All cases received two doses of DB on days 0 and 14, resulting in a mean lesion size reduction of 17.75%.
Conclusion
Our findings suggest that this treatment regimen can significantly improve outcomes for patients with aggressive GCTB, aiding orthopaedic oncologists in managing these challenging cases more effectively.
Statements and Declarations
The authors declare no competing or financial interests. No funding was received for this study.
Principles of Declaration of Helsinki were followed in this retrospective analysis.
Authors' Contributions
R.B.S. conceived the idea and revised the manuscript. S.K.J. collected the data and wrote the manuscript. K.V. analyzed the data and also contributed to writing the manuscript.
Publikationsverlauf
Eingereicht: 02. Oktober 2024
Angenommen: 24. März 2025
Artikel online veröffentlicht:
23. April 2025
© 2025. MedIntel Services Pvt Ltd. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)
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