Glycosylation and Immune Evasion in Neuroblastoma

Neuroblastoma (NB) is the most common extracranial solid tumor in children, with high-risk cases exhibiting poor prognosis despite intensive multimodal treatment. The tumor's genetic and molecular heterogeneity complicates therapy, underscoring the need for novel therapeutic strategies. Our study investigates key regulatory mechanisms in NB, particularly the role of glycosyltransferases in immune evasion and tumor progression. Dysregulated glycosylation patterns alter immune recognition and impact NB aggressiveness, providing potential targets for intervention. Our findings contribute to the understanding of NB pathophysiology and highlight glycosylation as a promising avenue for therapeutic exploration. Targeting glycosylation-related mechanisms may enhance treatment efficacy and improve patient outcomes.

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Artikel online veröffentlicht:
09. Mai 2025