CC BY-NC-ND 4.0 · Revista Chilena de Ortopedia y Traumatología 2025; 66(01): e42-e52
DOI: 10.1055/s-0045-1809038
Artículo de Revisión | Review Article

Manejo de la Infección Periprotésica. Revisión de la Literatura Actual y Algoritmo de Manejo

Article in several languages: español | English
1   Servicio de Cirugía Ortopédica y Traumatología, Hospital Clínico Universitario de Valencia, Valencia, España
,
Luis Díaz Aviñó
1   Servicio de Cirugía Ortopédica y Traumatología, Hospital Clínico Universitario de Valencia, Valencia, España
,
Prario Massimino Paula
1   Servicio de Cirugía Ortopédica y Traumatología, Hospital Clínico Universitario de Valencia, Valencia, España
› Author Affiliations

Resumen

Objetivo Este artículo revisa exhaustivamente el manejo de la infección periprotésica en ortopedia, basándose en consensos internacionales recientes para guiar un enfoque terapéutico que asegure la recuperación funcional del paciente.

Materiales y Métodos Se exploran diversas estrategias terapéuticas, como el desbridamiento con retención del implante (DAIR), recambios en uno y dos tiempos, y el uso de espaciadores de liberación antibiótica. Se presentan escalas de predicción como CRIME80 y KLIC para evaluar el riesgo de fracaso en cada intervención.

Resultados El DAIR tiene una tasa de éxito aproximada del 71% en infecciones agudas, siempre que se cumplan criterios específicos, como una duración corta de los síntomas y microorganismos sensibles a los antibióticos disponibles. Las escalas CRIME80 y KLIC permiten estimar el riesgo de fracaso en infecciones agudas y postquirúrgicas, respectivamente. El recambio en un solo tiempo es viable en pacientes seleccionados, aunque el recambio en dos tiempos sigue siendo el estándar para casos complejos.

Discusión Los resultados subrayan que un abordaje multidisciplinario, incluyendo microbiología y enfermedades infecciosas, y el uso de escalas predictivas son esenciales para mejorar los resultados terapéuticos y personalizar el tratamiento.

Conclusiones El éxito en el manejo de la infección periprotésica exige un enfoque que considere la biología del biofilm y permita una selección cuidadosa del tratamiento. Al integrar los últimos avances en diagnóstico y tratamiento quirúrgico, se pueden mejorar significativamente los resultados clínicos y la calidad de vida del paciente.

Nivel de evidencia: IV.



Publication History

Received: 19 March 2025

Accepted: 02 April 2025

Article published online:
20 May 2025

© 2025. Sociedad Chilena de Ortopedia y Traumatologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

Thieme Revinter Publicações Ltda.
Rua Rego Freitas, 175, loja 1, República, São Paulo, SP, CEP 01220-010, Brazil

 
  • Referencías

  • 1 Insall JN, Thompson FM, Brause BD. Two-stage reimplantation for the salvage of infected total knee arthroplasty. J Bone Joint Surg Am 1983; 65 (08) 1087-1098
  • 2 Konigsberg BS, Hartman CW, Hewlett AL, Garvin KL. Current and future trends in the diagnosis of periprosthetic hip infection. Orthop Clin North Am 2014; 45 (03) 287-293
  • 3 Esteban J, Sorlí L, Alentorn-Geli E, Puig L, Horcajada JP. Conventional and molecular diagnostic strategies for prosthetic joint infections. Expert Rev Mol Diagn 2014; 14 (01) 83-96
  • 4 Spiegel C, Coraça-Huber DC, Nogler M, Arora R, Putzer D. Cold Plasma Activity Against Biofilm Formation of Prosthetic Joint Infection Pathogens. Pathogens 2024; 14 (01) 10
  • 5 Del Pozo JL, Patel R. Clinical practice. Infection associated with prosthetic joints. N Engl J Med 2009; 361 (08) 787-794
  • 6 Qasim SN, Swann A, Ashford R. The DAIR (debridement, antibiotics and implant retention) procedure for infected total knee replacement - a literature review. SICOT J 2017; 3: 2
  • 7 Kuiper JW, Vos SJ, Saouti R. et al. Prosthetic joint-associated infections treated with DAIR (debridement, antibiotics, irrigation, and retention): analysis of risk factors and local antibiotic carriers in 91 patients. Acta Orthop 2013; 84 (04) 380-386
  • 8 Longo UG, De Salvatore S, Bandini B. et al. Debridement, antibiotics, and implant retention (DAIR) for the early prosthetic joint infection of total knee and hip arthroplasties: a systematic review. J ISAKOS 2024; 9 (01) 62-70
  • 9 Achermann Y, Stasch P, Preiss S, Lucke K, Vogt M. Characteristics and treatment outcomes of 69 cases with early prosthetic joint infections of the hip and knee. Infection 2014; 42 (03) 511-519
  • 10 Chalmers BP, Kapadia M, Chiu YF. et al. Accuracy of Predictive Algorithms in Total Hip and Knee Arthroplasty Acute Periprosthetic Joint Infections Treated With Debridement, Antibiotics, and Implant Retention (DAIR). J Arthroplasty 2021; 36 (07) 2558-2566
  • 11 Sabater-Martos M, Hernández Hermoso JA, García Oltra E, Molinos S, Martínez-Pastor JC. Validity of the KLIC and CRIME80 scores in predicting failure in late acute infection treated by debridement and implant retention. Rev Esp Cir Ortop Traumatol (Engl Ed) 2020; 64 (06) 415-420
  • 12 Choi HR, von Knoch F, Zurakowski D, Nelson SB, Malchau H. Can implant retention be recommended for treatment of infected total knee arthroplasty?. Clin Orthop Relat Res 2011; 469 (04) 961-969
  • 13 Lora-Tamayo J, Murillo O, Iribarren JA. et al; REIPI Group for the Study of Prosthetic Infection. A large multicenter study of methicillin-susceptible and methicillin-resistant Staphylococcus aureus prosthetic joint infections managed with implant retention. Clin Infect Dis 2013; 56 (02) 182-194
  • 14 Tai DBG, Berbari EF, Suh GA, Lahr BD, Abdel MP, Tande AJ. Truth in DAIR: Duration of Therapy and the Use of Quinolone/Rifampin-Based Regimens After Debridement and Implant Retention for Periprosthetic Joint Infections. Open Forum Infect Dis 2022; 9 (09) ofac363
  • 15 Miller R, Higuera CA, Wu J, Klika A, Babic M, Piuzzi NS. Periprosthetic Joint Infection: A Review of Antibiotic Treatment. JBJS Rev 2020; 8 (07) e1900224
  • 16 Vilchez F, Martínez-Pastor JC, García-Ramiro S. et al. Outcome and predictors of treatment failure in early post-surgical prosthetic joint infections due to Staphylococcus aureus treated with debridement. Clin Microbiol Infect 2011; 17 (03) 439-444
  • 17 Lizaur-Utrilla A, Gonzalez-Parreño S, Gil-Guillen V, Lopez-Prats FA. Debridement with prosthesis retention and antibiotherapy vs. two-stage revision for periprosthetic knee infection within 3 months after arthroplasty: a case-control study. Clin Microbiol Infect 2015; 21 (09) 851.e11-851.e17
  • 18 Kildow BJ, Della-Valle CJ, Springer BD. Single vs 2-Stage Revision for the Treatment of Periprosthetic Joint Infection. J Arthroplasty 2020; 35 (3S): S24-S30
  • 19 Zahar A, Gehrke TA. One-Stage Revision for Infected Total Hip Arthroplasty. Orthop Clin North Am 2016; 47 (01) 11-18
  • 20 Bialecki J, Bucsi L, Fernando N. et al. S. McHale, Robert Molloy, Michael A. Mont, Rhidian Morgan-Jones, Malte Ohlmeier, Ariel Saldaña, Nipun Sodhi, Andrew Toms, R. Walker, Akos Zahar, Hip and Knee Section, Treatment, One Stage Exchange: Proceedings of International Consensus on Orthopedic Infections,The Journal of Arthroplasty, Volume 34, Issue 2, Supplement, 2019, Pages S421-S426, ISSN 0883-5403
  • 21 Nagra NS, Hamilton TW, Ganatra S, Murray DW, Pandit H. One-stage versus two-stage exchange arthroplasty for infected total knee arthroplasty: a systematic review. Knee Surg Sports Traumatol Arthrosc 2016; 24 (10) 3106-3114
  • 22 Johnson AJ, Sayeed SA, Naziri Q, Khanuja HS, Mont MA. Minimizing dynamic knee spacer complications in infected revision arthroplasty. Clin Orthop Relat Res 2012; 470 (01) 220-227
  • 23 Lichstein P, Su S, Hedlund H. et al. Treatment of periprosthetic knee infection with a two-stage protocol using static spacers. Clin Orthop Relat Res 2016; 474 (01) 120-125
  • 24 Marson BA, Walters ST, Bloch BV, Sehat K. Two-stage revision surgery for infected total knee replacements: reasonable function and high success rate with the use of primary knee replacement implants as temporary spacers. Eur J Orthop Surg Traumatol 2018; 28 (01) 109-115
  • 25 Kusuma SK, Ward J, Jacofsky M, Sporer SM, Della Valle CJ. What is the role of serological testing between stages of two-stage reconstruction of the infected prosthetic knee?. Clin Orthop Relat Res 2011; 469 (04) 1002-1008
  • 26 Triantafyllopoulos GK, Memtsoudis SG, Zhang W, Ma Y, Sculco TP, Poultsides LA. Periprosthetic infection recurrence after 2-stage exchange arthroplasty: failure or fate?. J Arthroplasty 2017; 32 (02) 526-531
  • 27 Li C, Renz N, Trampuz A, Ojeda-Thies C. Twenty common errors in the diagnosis and treatment of periprosthetic joint infection. Int Orthop 2020; 44 (01) 3-14