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CC BY 4.0 · Libyan International Medical University Journal
DOI: 10.1055/s-0045-1809157
Case Report

A Rare Case of Amelanotic Mucosal Malignant Melanoma of the Penis: First of Its Kind Case Report from India

Soundarya Varadarajan
1   Department of Surgical Oncology, HCG Manavata Cancer Centre, Nashik, Maharashtra, India
,
Vikas Jain
1   Department of Surgical Oncology, HCG Manavata Cancer Centre, Nashik, Maharashtra, India
,
Raj Nagarkar
1   Department of Surgical Oncology, HCG Manavata Cancer Centre, Nashik, Maharashtra, India
,
Sucheta Gandhe
2   Department of Pathology, HCG Manavata Cancer Centre, Nashik, Maharashtra, India
,
Yasam Venkata Ramesh
3   Department of Academics, HCG Manavata Cancer Centre, Nashik, Maharashtra, India
› Author Affiliations Funding None.
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Abstract

Amelanotic mucosal malignant melanoma of the penis is extremely rare. To our knowledge, this is the first case from India. In the present case report, we have discussed the diagnostic challenges, treatment, and prognosis related with this rare condition. A 55-year-old male presented with a 2-month history of a nonhealing penile ulcer. This duration reflects delayed presentation, as the diagnosis was only confirmed following comprehensive diagnostic workup, including imaging and immunohistochemistry. Partial penectomy with 2 cm margin with sentinel lymph node biopsy was performed. The postoperative period was uneventful. Currently, the patient is on close follow-up. In exceptionally rare cases like this, lack of melanin pigmented lesions may delay the diagnosis and management process. In such scenarios, knowledge related to this rare condition will promptly help the clinicians in early diagnosis, which will be a key for effective treatment and better prognosis of the patient.

Keywords

amelanotic - mucosal - malignant melanoma - penis - case report

Availability of Data and Materials

The data set used and/or analyzed during the current study is available from the corresponding author on reasonable request.




Publication History

Received: 28 March 2025

Accepted: 21 April 2025

Article published online:
19 May 2025

© 2025. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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