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CC BY-NC-ND 4.0 · South Asian J Cancer
DOI: 10.1055/s-0045-1809352
Original Article

Clinical and Survival Insights into Carcinoma Penis: A Retrospective Analysis at a Tertiary Care Facility

Authors

  • Santosh Kumar Swain 

    1   Department of Medical Oncology, Institute of Medical Sciences and Sum Hospital, Siksha ‘O’ Anusandhan Deemed to be University, Bhubaneswar, Odisha, India

  • Lalatendu Moharana 

    1   Department of Medical Oncology, Institute of Medical Sciences and Sum Hospital, Siksha ‘O’ Anusandhan Deemed to be University, Bhubaneswar, Odisha, India

  • Ghanashyam Biswas

    1   Department of Medical Oncology, Institute of Medical Sciences and Sum Hospital, Siksha ‘O’ Anusandhan Deemed to be University, Bhubaneswar, Odisha, India

  • Lipsita Samantaray 

    1   Department of Medical Oncology, Institute of Medical Sciences and Sum Hospital, Siksha ‘O’ Anusandhan Deemed to be University, Bhubaneswar, Odisha, India

  • Ayush Dubey 

    1   Department of Medical Oncology, Institute of Medical Sciences and Sum Hospital, Siksha ‘O’ Anusandhan Deemed to be University, Bhubaneswar, Odisha, India

  • Reetu Singhal

    1   Department of Medical Oncology, Institute of Medical Sciences and Sum Hospital, Siksha ‘O’ Anusandhan Deemed to be University, Bhubaneswar, Odisha, India

  • Bhavya Inimerla 

    1   Department of Medical Oncology, Institute of Medical Sciences and Sum Hospital, Siksha ‘O’ Anusandhan Deemed to be University, Bhubaneswar, Odisha, India

  • Antara Sanyal 

    1   Department of Medical Oncology, Institute of Medical Sciences and Sum Hospital, Siksha ‘O’ Anusandhan Deemed to be University, Bhubaneswar, Odisha, India

  • Swati Sucharita Mohanty 

    1   Department of Medical Oncology, Institute of Medical Sciences and Sum Hospital, Siksha ‘O’ Anusandhan Deemed to be University, Bhubaneswar, Odisha, India

  • Soumya Surath Panda 

    1   Department of Medical Oncology, Institute of Medical Sciences and Sum Hospital, Siksha ‘O’ Anusandhan Deemed to be University, Bhubaneswar, Odisha, India

Funding None.
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Abstract

Objective

The main objective was to evaluate key survival results, comprising progression-free survival (PFS) and overall survival (OS), in individuals with histopathologically confirmed penile cancer, along with an assessment of clinical features, treatment strategies, and therapy-related side effects.

Materials and Methods

This study comprised retrospective analyses of individuals diagnosed with penile cancer, confirmed by histology, between April 2021 and December 2024, regardless of disease stage. Case records were reviewed to gather information on demographics, clinical details, histopathology, and treatment outcomes.

Statistical Analysis

As the data was collected retrospectively, no prior sample size estimate was performed. Data analysis was carried out using SPSS version 27.

Results

The most common presenting symptoms were ulcerative-proliferative growth (60%), pain (50%), dysuria (40%), and lymphedema (40%). The median age of patients in this retrospective study was 56 years (interquartile range: 49.25–59.25). Out of the 10 patients included, 9 (90%) had localized or locally advanced disease and underwent primary surgical treatment. Among them, eight patients (80%) had partial penectomy, while one patient (10%) underwent total penectomy. These patients received adjuvant chemotherapy and/or radiotherapy based on their disease stage. One patient (10%) had metastatic disease at diagnosis and was treated with upfront palliative chemotherapy. Most patients presented with advanced-stage tumors, with 60% having T3/T4 disease and 90% showing lymph node involvement (N + ). For those with nonmetastatic disease, the median disease-free survival was 14 months (95% confidence interval [CI]: 12.61–15.38). Following disease progression, patients were treated with palliative intent, achieving a median PFS of 12 months (95% CI: 11.29–12.71) and a median OS of 28 months (95% CI: 24.9–31.09). Two patients (20%) experienced grade 3 or higher neutropenia, and one patient had hypothyroidism.

Conclusion

In India, penile cancer is frequently identified at an advanced stage. Patients presenting with recurrent, metastatic, or nodal disease tend to have poor OS, even with optimal palliative systemic therapy. This highlights a significant unmet need for more effective systemic treatment options in this group. Our study underscores the pressing need for region-specific research and improved access to multidisciplinary care.

Keywords

clinical profile - survival - carcinoma penis - overall survival - disease-free survival - progression-free survival

Authors' Contributions

All authors contributed equally and did the critical revision of the final manuscript. All authors read and approved the final manuscript.


Declaration of Generative AI

The authors declare that they have not used any generative artificial intelligence (AI) and AI-assisted technologies in the writing process.


Patient Consent

Informed consent was obtained from all the patients for both participation and publication of the details.


Ethical Approval

This study was approved by the institutional review board and the patient's consent was taken. All procedures performed in our study involving any human participation were in accordance with the ethical standards of the institutional and/or national research committee and in compliance with the 1964 Helsinki Declaration and its later amendments.


Availability of Data and Material

All data generated or analyzed during this study are included in this published article, and referenced articles are listed in the reference section.




Publikationsverlauf

Eingereicht: 11. März 2025

Angenommen: 02. Mai 2025

Artikel online veröffentlicht:
22. Mai 2025

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