Tratamento da dor lombar com uma combinação de trifosfato de uridina, monofosfato de citidina e hidroxicobalamina: Uma revisão sistemática e metanálise

Resumo

A dor lombar é uma queixa comum. Essa síndrome tem diferentes mecanismos subjacentes, difíceis de diferenciar em tempo hábil apenas por meio dos recursos semióticos, laboratoriais e de imagem disponíveis no atendimento de emergência. Isso faz com que os profissionais tendam a uma abordagem sintomática inicial composta por medicamentos (anti-inflamatórios não esteroidais, analgésicos, relaxantes musculares) ou procedimentos locais (calor local, massagem). Substâncias neurotróficas periféricas, como nucleotídeos de pirimidina (trifosfato de uridina e monofosfato de citidina) combinados com vitamina B12 (hidroxicobalamina), têm sido usadas como precursores anabólicos capazes de fornecer às raízes nervosas espinhais elementos desencadeadores úteis para a regeneração de neurônios e células da glia, uma vez que um provável mecanismo de compressão espinhal seja contido. Os autores realizaram uma revisão sistemática e meta-análise com a combinação acima com o objetivo de determinar melhor seu papel no tratamento da dor lombar.

Abstract

Low back pain is a common complaint. This syndrome comprehends different underlying mechanisms, which are difficult to differentiate in a timely manner only through semiotic, laboratory, and imaging resources available in an emergency setting. Such circumstances make practitioners prone to an initial symptomatic approach in the form of medications (non-steroid anti-inflammatory drugs, analgesics, muscle relaxants) or local procedures (local heat, massage). Peripheral neurotrophic substances, such as pyrimidine nucleotides (uridine triphosphate and cytidine monophosphate) combined with vitamin B12 (hydroxocobalamin), have been used as anabolic precursors able to provide spinal nerve roots with triggering elements useful for nerve and glial cells regeneration, once a likely spinal compression mechanism is contained. The authors performed a systematic review and meta-analysis with the above combination with the aim of better determining its role in low back pain management.

Palavras-chave

dor lombar - hidroxicobalamina - monofosfato de citidina - raízes nervosas espinhais - uridina trifosfato

Keywords

cytidine monophosphate - hydroxocobalamin - low back pain - spinal nerve roots - uridine triphosphate

Publication History

Received: 06 September 2024

Accepted: 25 October 2024

Article published online:
10 July 2025

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