Abstract
Background
This study aimed to determine factors influencing the latent period in pregnant women
with periviable preterm premature rupture of membranes (PPROM) between 22 and 26 weeks
of gestation.
Methods
A retrospective analysis of 106 pregnant women who delivered at our hospital between
2017 and 2021 was conducted. Diagnosis was confirmed using sterile speculum examination
or the AmniSure test. Standard treatment included antibiotics, steroids, and tocolytic
therapy. Maternal and fetal data, including C-reactive protein (CRP) levels, hemogram
parameters, birth weight, and APGAR (Appearance, Pulse, Grimace, Activity, and Respiration)
scores, were collected from medical records.
Results
A statistically significant difference was observed between CRP levels and the latent
period. Patients with negative CRP values (< 5 mg/L) had a longer latent period (18.9 ± 17.05
days) compared with those with positive CRP values (> 5 mg/L, 8.47 ± 17.07 days).
Chorioamnionitis was detected in 8 of 31 newborns, with a significant association
between chorioamnionitis and necrotizing enterocolitis (NEC) (p = 0.043).
Conclusion
PPROM poses significant maternal and neonatal risks, with the latent period directly
impacting outcomes. Elevated CRP levels at admission were linked to shorter latency
(p < 0.05), while tocolytic therapy prolonged latency without improving neonatal outcomes.
The association between chorioamnionitis and NEC (p = 0.043) highlights the importance of early identification and management of risk
factors. Individualized treatment with tocolytics, antibiotics, and corticosteroids
is essential to optimize maternal and neonatal outcomes.
Keywords
preterm premature rupture of membranes - latent period - chorioamnionitis - respiratory
distress syndrome
